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| 標題: | Tocilizumab, a Humanized Monoclonal Antibody Against the Interleukin-6 Receptor, Inhibits High Glucose-Induced Vascular Smooth Muscle Cell Migration Through Mitogen-Activated Protein Kinase Signaling Pathways |
| 作者: | Wu, Tao-Cheng
Chiang, Chih-Yao
Chan, Jenq-Shyong
Lee, Chiu-Yang
Leu, Hsin-Bang
Huang, Po-Hsun
Chen, Jia-Shiong
Lin, Shing-Jong
Chen, Jaw-Wen |
| 貢獻者: | Natl Yang Ming Univ, Cardiovasc Res Ctr
Taipei Vet Gen Hosp, Div Cardiol, Dept Med
Taipei City Hosp, Div Cardiovasc Surg
Armed Forces Tao Yuan Gen Hosp, Div Nephrol
Taipei Vet Gen Hosp, Div Cardiovasc Surg, Dept Surg
Chia Nan Univ Pharm & Sci, Dept Senior Citizen Serv Management
Taipei Vet Gen Hosp, Hlth Care & Serv Ctr
Taipei Vet Gen Hosp, Dept Med Res & Educ
Natl Yang Ming Univ, Inst Pharmacol, Inst Clin Med, Sch Med |
| 關鍵字: | tocilizumab
human aortic smooth muscle cells
interleukin-6 receptor
glucose
diabetes |
| 日期: | 2018-11-01 |
| 上傳時間: | 2019-11-15 15:46:05 (UTC+8) |
| 出版者: | MARY ANN LIEBERT, INC |
| 摘要: | Rheumatoid arthritis (RA) with diabetes increases the risk of cardiovascular diseases. Interleukin-6 (IL-6) promotes the disease activity of RA and insulin resistance. This study aimed to evaluate the potential effects and molecular mechanisms of IL-6 blocker, tocilizumab, in atherosclerosis with diabetes. Human aortic smooth muscle cells (HASMCs) cultured under hyperglycemic conditions were evaluated for migration, expression of adhesion molecules, and matrix metalloproteinases before and after treatment with tocilizumab. High glucose (HG) significantly increased expression of IL-6, intercellular adhesion molecule (ICAM-1), matrix metalloproteinase-2 & 9, and migration of vascular smooth muscle cells. Tocilizumab suppressed HG-induced expression of ICAM-1, MMP-2, and MMP-9. Pretreatment with tocilizumab also inhibited migration, MAPK signaling, and nuclear translocation of p65-NF-kappa B in HG-stimulated HASMCs. Our data suggested that tocilizumab may exert an antiatherosclerotic activity in diabetes. |
| link: | http://dx.doi.org/10.1089/jir.2018.0009 |
| 關聯: | Cancers, v.38, n.11, pp.510-516 |
| 顯示於類別: | [高齡福祉養生管理系] 期刊論文
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