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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32220

    標題: Risk Factors for the Progression of Mild Cognitive Impairment in Different Types of Neurodegenerative Disorders
    作者: Chen, Pei-Hao
    Cheng, Shih-Jung
    Lin, Hui-Chi
    Lee, Chuo-Yu
    Chou, Chih-Ho
    貢獻者: MacKay Mem Hosp, Dept Neurol
    Mackay Med Coll, Dept Med
    Natl Taipei Univ Technol, Grad Inst Mech & Elect Engn
    Natl Yang Ming Univ, Dept Phys Therapy & Assist Technol
    Tamkang Univ, Grad Inst Chem
    Chi Mei Med Ctr, Dept Neurol
    Chia Nan Univ Pharm & Sci
    關鍵字: Alzheimers Association Workgroups
    Society Task-Force
    Diagnostic Guidelines
    National Institute
    Clinical Dementia
    日期: 2018
    上傳時間: 2019-11-15 15:45:40 (UTC+8)
    出版者: HINDAWI LTD
    摘要: Objective. Mild cognitive impairment (MCI) is a transitional state between normal aging and early dementia. It has a heterogeneous etiology and clinical course. This study aimed to examine the factors associated with the progression of MCI in different types of dementia disorders. Method. A retrospective, longitudinal, observational study of outpatients with MCI was conducted at a medical center in northern Taiwan. Patient medical records were reviewed, and risk factors were analyzed by multivariate analysis. Results. Among 279 patients with MCI, 163 (58.4%), 68 (24.4%), and 48 (17.2%) were diagnosed with Alzheimer's disease, vascular cognitive impairment, and Lewy body diseases, respectively. During the observation period, 37.2% of patients progressed to dementia. Older age and a higher Clinical Dementia Rating Scale-Sum of Boxes were associated with the risk of progression. Hyperlipidemia was associated with a decreased risk. Converters were more likely to receive an antidementia prescription. Conclusion. Our study suggests the importance of comprehensive clinical profiling, risk factor assessment, and detailed drug history evaluations in improving our understanding and management of dementia subtypes.
    link: http://dx.doi.org/10.1155/2018/6929732
    關聯: Cell Biochemistry and Biophysics, v.2018, ID 6929732
    Appears in Collections:[通識教育中心] 期刊論文

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