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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32210

    標題: Propensity-matched analysis of the impact of extended-spectrum beta-lactamase production on adults with community-onset Escherichia coli, klebsiella species, and Proteus mirabilis bacteremia
    作者: Lee, Ching-Chi
    Lee, Chung-Hsun
    Hong, Ming-Yuan
    Hsieh, Chih-Chia
    Tang, Hung-Jen
    Ko, Wen-Chien
    貢獻者: Madou Sin Lau Hosp, Dept Internal Med
    Chang Jung Christian Univ, Coll Hlth Sci, Grad Inst Med Sci
    Natl Cheng Kung Univ Hosp, Dept Internal Med
    Natl Cheng Kung Univ, Dept Med, Med Coll
    Natl Cheng Kung Univ Hosp, Dept Emergency Med
    Chi Mei Med Ctr, Dept Med
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    關鍵字: Bacteremia
    Escherichia coli
    Klebsiella species
    Proteus mirabilis
    日期: 2018-08
    上傳時間: 2019-11-15 15:45:18 (UTC+8)
    摘要: Background: The presence of extended-spectrum beta-lactamase (ESBL) in Escherichia coli, Klebsiella species, and Proteus mirabilis (EKP) is of great microbiological and clinical importance. The study dealing with the direct impact of ESBL producers on the outcome of patients with community-onset bacteremia is lacking. Methods: Adults with community-onset EKP bacteremia were recruited retrospectively during a 6-year period. ESBL producers were determined according to ESBL phenotype. ESBL patients were compared on a 1:2 basis with non-ESBL patients by using propensity-score matching(PSM) calculated based on independent predictors of 28-day mortality. Results: Of the 1141 eligible adult patients, 65 (5.7%) caused by ESBL producers. Significant differences between the two groups were discovered in the proportions of patients with critical illness (a Pitt bacteremia score >= 4) at bacteremia onset, inappropriate empirical antibiotic therapy, bacteremia because of urosepsis and pneumonia, and several comorbidities. In a PSM analysis after controlling for six independent predictors-critical illness at bacteremia onset, underlying fatal comorbidities (McCabe classification), inappropriate empirical antibiotic therapy, comorbidities with liver cirrhosis, bacteremia because of urosepsis and pneumonia-a appropriate matching between two groups (ESBL group, 60 patients; non-ESBL group, 120) were observed in age, causative microorganism, bacteremia severity, major comorbidities, comorbidity severity, and major bacteremia source. Consequently, a strong relationship between ESBL producers and poor prognosis was highlighted. Conclusions: The adverse influence of ESBL producers on clinical outcomes was presented with respect to adults with community-onset EKP bacteremia. Establishing a predictive scoring algorithm for identifying patients at risk of ESBL-producer infections is crucial. Copyright (C) 2017, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
    link: http://dx.doi.org/10.1016/j.jmii.2017.05.006
    關聯: Journal of Microbiology Immunology and Infection, v.51, n.4, pp.519-526
    Appears in Collections:[保健營養系(所) ] 期刊論文

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