We found significant correlation between the incidence of severe influenza and Aspergillus antigenemia among medical intensive care unit patients for 7-month observation (coefficient gamma = 0.976, p < 0.001). High-level ambient pollution was noticed for 2 months before the epidemic, highlighting that influenza patients might coinfect with aspergillosis in the community. Copyright (C) 2017, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.