Appropriate composites of cefoperazone-sulbactam against multidrug-resistant organisms

doi:10.2147/IDR.S175257

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標題:	Appropriate composites of cefoperazone-sulbactam against multidrug-resistant organisms
作者:	Lai, Chih-Cheng Chen, Chi-Chung Lu, Ying-Chen Lin, Tsuey-Pin Chuang, Yin-Ching Tang, Hung-Jen
貢獻者:	Chi Mei Med Ctr, Dept Intens Care Med Chi Mei Med Ctr, Dept Med Res Natl Chiayi Univ, Dept Food Sci Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Chi Mei Med Ctr, Dept Internal Med Chi Mei Med Ctr, Dept Med
關鍵字:	cefoperazone-sulbactam extended-spectrum beta-lactamases Escherichia coli Klebsiella pneumoniae multidrug-resistant organisms
日期:	2018
上傳時間:	2019-11-15 15:43:53 (UTC+8)
出版者:	DOVE MEDICAL PRESS LTD
摘要:	Objectives: This study aims to assess the in vitro activity of different cefoperazone-sulbactam ratios against different multidrug-resistant organisms (MDROs). Materials and methods: Minimum inhibitory concentrations (MICs) and susceptibility rates of cefoperazone, sulbactam and cefoperazone-sulbactam at fixed ratios of 2:1, 1:1 and 1:2 against 344 MDRO clinical isolates, including extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (n=58), ESBL-producing Klebsiella pneumoniae (n=58), carbapenem-resistant Enterobacteriaceae (n=57), carbapenem-resistant Pseudomonas aeruginosa (n=49) and carbapenem-resistant Acinetobacter baumannii (n=122), were measured. Results: Combined treatment with sulbactam and cefoperazone resulted in decreased MIC50 values across all MDROs, as well as decreases in most MIC90 values, except for carbapenem-resistant Enterobacteriaceae and carbapenem-resistant P. aeruginosa (MIC90 values remained >64 mg/L). Susceptibility rates of treatment with cefoperazone alone against all MDROs were much lower than that of cefoperazone-sulbactam combination (all P<0.05), except in carbapenem-resistant P. aeruginosa. Additionally, the susceptibility rate gradually increased as the ratio of cefoperazone-sulbactam was adjusted from 2:1 to 1:1 and to 1:2 for carbapenem-resistant Enterobacteriaceae, ESBL-producing K. pneumoniae and carbapenem-resistant A. baumannii. There were no significant ratio-dependent changes in susceptibility rates with cefoperazone-sulbactam in carbapenem-resistant P. aeruginosa. Conclusion: Adding sulbactam enhances cefoperazone activity against most MDROs excluding carbapenem-resistant P. aeruginosa, and the activity of cefoperazone-sulbactam against these MDROs is greatest at a ratio of 1: 2, followed by ratios of 1:1 and 2:1.
link:	http://dx.doi.org/10.2147/IDR.S175257
關聯:	Infection and Drug Resistance, v.11, pp.1441-1445
顯示於類別:	[保健營養系(所) ] 期刊論文

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