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    標題: Risk factors and mortality of adults with lung cancer admitted to the intensive care unit
    作者: Lai, Chih-Cheng
    Ho, Chung-Han
    Chen, Chin-Ming
    Chiang, Shyh-Ren
    Chao, Chien-Ming
    Liu, Wei-Lun
    Wang, Jhi-Joung
    Yang, Ching-Chieh
    Cheng, Kuo-Chen
    貢獻者: Chi Mei Med Ctr, Dept Intens Care Med
    Chi Mei Med Ctr, Dept Med Res
    Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
    Chi Mei Med Ctr, Dept Intens Care Med
    Chia Nan Univ Pharm & Sci
    Chi Mei Med Ctr, Internal Med
    Fu Jen Catholic Univ Hosp, Dept Emergency & Crit Care Med
    Chi Mei Med Ctr, Dept Radiat Oncol[Yang, Ching-Chieh
    Natl Sun Yat Sen Univ, Inst Biomed Sci
    Chia Nan Univ Pharm & Sci, Dept Biotechnol
    Chung Hwa Univ Med Technol, Dept Safety Hlth & Environm Engn
    關鍵字: Lung cancer
    intensive care unit mortality
    risk factor
    日期: 2018-07
    上傳時間: 2019-11-15 15:43:03 (UTC+8)
    出版者: AME PUBL CO
    摘要: Background: This study aims to investigate lung cancer patients' risk factors for: intensive care unit (ICU) admission, infectious complications and organ dysfunction in the ICU, and prognosis after ICU admission. Methods: The records of all patients with lung-cancer catastrophic-illness cards admitted to the ICU between 2003 and 2012 were reviewed. The primary endpoint was 1 -year mortality. Results: We finally analyzed the records of index-date-, age-, and sex-matched ICU-admitted (ICU+) lung cancer patients (n = 17,687) and ICU-non-admittcd (TCU-) lung cancer patients (n=35,374). The overall 1 -year mortality rate was significantly(p<0.0001) higher for ICU+ patients (49.91%) than for ICU- patients (44.86%). Most ICU+ patients (56.16%) had infectious complications and organ dysfunction (52.33%), and overall, 6,893 (38.97%) had sepsis. Independent mortality risk factors were age (>= 75 years) [adjusted hazard ratio AHR), 1.22; 95% confidence interval (CI), 1.16-1.29], male sex: AHR, 1.18; 95% CI, 1.13-1.23), recent radiotherapy (AHR, 1.09; 95% CI, 1.04-1.15), infectious complications (AHR: 1.23; 95% CI: 1.17-1.29), organ dysfunction (AHR, 1.57; 95% CI, 1.50-1.65), and hospital level (regional hospital: AHR, 1.11; 95% CI, 1.06-1.16; local hospital: AHR, 1.28; 95% CI, 1.18-1.37). Conclusions: ICU admission for lung cancer patients is associated with higher mortality. Several risk factors of mortality for ICU(+ )patients should help physicians provide patients personalized and better-informed lung cancer therapy decisions.
    關聯: Journal of Thoracic Disease, v.10, n.7, pp.4118-4126
    顯示於類別:[生物科技系(所)] 期刊論文


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