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| 標題: | Treatment of beta-thujaplicin counteracts di(2-ethylhexyl)phthalate (DEHP)-exposed vascular smooth muscle activation, inflammation and atherosclerosis progression |
| 作者: | Shih, Mei Fen
Pan, Kuang-Hung
Liu, Chia-Chyuan
Shen, Chia-Rui
Cherng, Jong Yuh |
| 貢獻者: | Chia Nan Univ Pharm & Sci, Dept Pharm
Natl Chung Cheng Univ, Dept Chem & Biochem
Chia Nan Univ Pharm & Sci, Dept & Inst Cosmet Sci
Chang Gung Univ, Dept Med Biotechnol & Lab Sci |
| 關鍵字: | 13-thujaplicin
DEHP
Plasticizer
E-selectin
ICAM-1
VCAM-1
MMP-2
MMP-9 |
| 日期: | 2018-02 |
| 上傳時間: | 2019-11-15 15:42:58 (UTC+8) |
| 出版者: | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 摘要: | The initiation of atherosclerosis involves up-regulation of molecules such as E-selectin, VCAM-1, and ICAM-1. The progression of atherosclerosis is linked to proliferation and migration of vascular smooth muscle cell via MMP-2 and MMP-9 activities. However, the etiology of atherosclerosis concerning plasticizers is unknown. We evaluated beta-thujaplicin in preventing the development of atherosclerosis in a model induced by pro-inflammatory cytokines. Moreover, we established a new atherosclerosis model in vascular smooth muscle cells (VSMC) exposed to a common contact plasticizer, di(2-ethylhexyl)phthalate (DEHP). SEVC4-10 endothelial cells were treated with 50% RAW conditioned medium and A7r5 VSMC was treated with the plasticizer, with/without beta-thujaplicin (4 or 12 mu M). Production of E-selectin, ICAM-1, and VCAM-1 in SEVC4-10 cells as well as MMP-2/MMP-9 (both expression and activity) in VSMC were monitored. Results showed that the conditioned medium induced E-selectin and ICAM were significantly prevented by beta-thujaplicin. However, inhibition on the production of VCAM by beta-thujaplicin was only seen in a concentration of 12 mu M. Both concentrations of beta-thujaplicin also significantly prevented DEHP-induced MMP-2 and MMP-9 expression and activities. Evidence uncovers that beta-thujaplicin has additional factors in amelioration of atherosclerosis and corroborates that beta-thujaplicin is a strong candidate in preventing the initiation and progression of atherosclerosis. |
| link: | http://dx.doi.org/10.1016/j.yrtph.2017.12.021 |
| 關聯: | Journal of Environmental Management, v.92, pp.333-337 |
| 顯示於類別: | [藥學系(所)] 期刊論文
[化妝品應用與管理系(所)] 期刊論文
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