One-Year Mortality of Patients with Chronic Kidney Disease After Spinal Cord Injury: A 14-Year Population-Based Study

doi:10.1016/j.wneu.2017.06.009

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Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/31799

Title:	One-Year Mortality of Patients with Chronic Kidney Disease After Spinal Cord Injury: A 14-Year Population-Based Study
Authors:	Yu, Shou-Chun Kuo, Jinn-Rung Shiue, Yow-Ling Yu, Zong-Xing Ho, Chung-Han Wu, Chia-Chun Wang, Jhi-Joung Chu, Chin-Chen Lim, Sher-Wei
Contributors:	Natl Sun Yat Sen Univ, Inst Biomed Sci Chi Mei Med Ctr, Chiali Branch, Dept Neurosurg Chi Mei Med Ctr, Chiali Branch, Dept Orthoped Chi Mei Med Ctr, Chiali Branch, Dept Med Res Chi Mei Med Ctr, Dept Nephrol Chi Mei Med Ctr, Dept Anesthesiol Min Hwei Coll Hlth Care Management, Dept Nursing Min Hwei Coll Hlth Care Management, Dept Dent Lab Technol Southern Taiwan Univ Sci & Technol, Dept Biotechnol Chia Nan Univ Pharm & Sci, Dept Pharm
Keywords:	Chronic kidney disease End-stage renal disease Mortality Population-based study Spinal cord injury Taiwan
Date:	2017-09
Issue Date:	2018-11-30 15:57:12 (UTC+8)
Publisher:	Elsevier Science Inc
Abstract:	OBJECTIVE: Chronic kidney disease (CKD) has become a global public health burden because of its increasing incidence, high risk of progression to end-stage renal disease (ESRD), and poor prognosis. We aimed to investigate the 1-year mortality of patients with spinal cord injury (SCI) with CKD and ESRD, and compare it with that of patients with SCI without CKD by reviewing a large Taiwanese population data set. METHODS: In this 14-year retrospective cohort study, the study group (SCI with CKD group, n = 3315) and comparison group (SCI without CKD group, n = 6630) were matched at a 1: 2 ratio with propensity score matching by age, sex, comorbidities, length of intensive care unit stay, and length of stay. The 1-year mortality and the relative risks of mortality were calculated. Mortality stratified by age, sex, and comorbidities was also analyzed. RESULTS: The SCI with CKD group had a significantly shorter survival period (10.13 vs. 10.97 months), higher 1-year mortality (17.65% vs. 8.54%), and higher risk of mortality than did the comparison group (adjusted hazard ratio, 2.25). Furthermore, patients with CKD with ESRD had a 7.71-fold higher risk of mortality than did patients with SCI without CKD for ages < 50 years. The presence of comorbidities was a risk factor for mortality among patients with SCI CKD or ESRD in contrast to patients with SCI without CKD. CONCLUSIONS: Patients with SCI with CKD, especially those with ESRD, have a higher risk of mortality than do patients who do not have CKD. Therefore, patients with CKD should have carefully monitoring for the development of 1-year mortality after SCI, especially for ESRD.
Relation:	World Neurosurgery, v.105, pp.462-469
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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