Effect of liver cirrhosis on long-term outcomes after acute respiratory failure: A population-based study

doi:10.3748/wjg.v23.i12.2201

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Title:	Effect of liver cirrhosis on long-term outcomes after acute respiratory failure: A population-based study
Authors:	Lai, Chih-Cheng Ho, Chung-Han Cheng, Kuo-Chen Chao, Chien-Ming Chen, Chin-Ming Chou, Willy
Contributors:	Chi Mei Med Ctr, Dept Intens Care Med Chi Mei Med Ctr, Dept Med Res Chi Mei Med Ctr, Internal Med Chung Hwa Univ Med Technol, Dept Safety Hlth & Environm Chia Nan Univ Pharm & Sci, Dept Recreat & Hlth Care Management
Keywords:	Liver cirrhosis Mechanical ventilation Outcome
Date:	2017-03-28
Issue Date:	2018-11-30 15:57:03 (UTC+8)
Publisher:	Baishideng Publishing Group Inc
Abstract:	AIM To assessed the effect of liver cirrhosis (LC) on the poorly understood long-term mortality risk after first-ever mechanical ventilation (1-MV) for acute respiratory failure. METHODS All patients in Taiwan given a 1-MV between 1997 and 2013 were identified in Taiwan's Longitudinal Health Insurance Database 2000. Each patient with LC was individually matched, using a propensity-score method, to two patients without LC. The primary outcome was death after a 1-MV. RESULTS A total of 16653 patients were enrolled: 5551 LC-positive (LC[Pos]) patients, including 1732 with cryptogenic LCs and 11102 LC-negative (LC[Neg]) controls. LC[Pos] patients had more organ failures and were more likely to be admitted to medical department than were LC[Neg] controls. LC[Pos] patients had a significantly lower survival rate (AHR = 1.38, 95%CI: 1.32- 1.44). Moreover, the mortality risk was significantly higher for patients with non-cryptogenic LC than for patients with cryptogenic LC (AHR = 1.43, 95%CI: 1.32- 1.54) and patients without LC (AHR = 1.56, 95%CI: 1.32- 1.54). However, there was no significant difference between patients with cryptogenic and without LC (HR = 1.05, 95% CI: 0.98- 1.12). CONCLUSION LC, especially non-cryptogenic LC, significantly increases the risk of death after a 1-MV.
Relation:	World Journal of Gastroenterology, v.23, n.12, pp.2201-2208
Appears in Collections:	[Dept. of Recreation and Health-Care Management] Periodical Articles

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