Electrochemical Oxidation of L-selenomethionine and Se-methylseleno-L-cysteine at a Thiol-Compound-Modified Gold Electrode: Its Application in a Flow-Through Voltammetric Sensor

doi:10.3390/s17020383

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Title:	Electrochemical Oxidation of L-selenomethionine and Se-methylseleno-L-cysteine at a Thiol-Compound-Modified Gold Electrode: Its Application in a Flow-Through Voltammetric Sensor
Authors:	Wang, Lai-Hao Zhang, Yu-Han
Contributors:	Chia Nan Univ Pharm & Sci, Dept Med Chem
Keywords:	thiol-modified gold electrodes amperometric detection L-selenomethionine Se-methylseleno-L-cysteine
Date:	2017-02
Issue Date:	2018-11-30 15:56:51 (UTC+8)
Publisher:	Mdpi Ag
Abstract:	A flow-electrolytic cell that consists of a bare gold wire or of different thiol-compound-modified gold electrodes ( such as 2,4-thiazolidinedione, 2-mercapto-5-thiazoline, 2-mercaptothiazoline, L-cysteine, thioglycolic acid) was designed to be used in a voltammetric detector to identify L-selenomethionine and Se-methylseleno- L-cysteine using high-performance liquid chromatography. Both L-selenomethionine and Se-methylseleno- L-cysteine are more efficiently electrochemically oxidized on a thiol/gold than on a bare gold electrode. For the DC mode, and for measurements with suitable experimental parameters, a linear concentration from 10 to 1600 ng.mL(-1) was found. The limits of quantification for L-selenomethionine and Se-methylseleno-L-cysteine were below 10 ng.mL(-1). The method can be applied to the quantitative determination of L-selenomethionine and Se-methylseleno-L-cysteine in commercial selenium-containing supplement products. Findings using high-performance liquid chromatography with a flow-through voltammetric detector and ultraviolet detector are comparable.
Relation:	Sensors, v.17, n.2, pp.383
Appears in Collections:	[Dept. of Food & Drug Industry and Inspective Technology] Periodical Articles

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