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| 標題: | VEGF expression correlates with neuronal differentiation and predicts a favorable prognosis in patients with neuroblastoma |
| 作者: | Weng, Wen-Chin
Lin, Kuan-Hung
Wu, Pei-Yi
Ho, Ya-Hsuan
Liu, Yen-Lin
Wang, Bo-Jeng
Chen, Chien-Chin
Lin, Yueh-Chien
Liao, Yung-Feng
Lee, Wang-Tso
Hsu, Wen-Ming
Lee, Hsinyu |
| 貢獻者: | Natl Taiwan Univ Hosp, Dept Pediat
Natl Taiwan Univ, Coll Med
Natl Taiwan Univ, Dept Life Sci
Acad Sinica, Inst Cellular & Organism Biol
Taipei Med Univ Hosp, Dept Pediat
Chia Yi Christian Hosp
Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
Natl Taiwan Univ Hosp, Dept Surg
Natl Taiwan Univ, Dept Elect Engn
Natl Taiwan Univ, Angiogenesis Res Ctr
Natl Taiwan Univ, Res Ctr Dev Biol & Regenerat Med
Natl Taiwan Univ, Ctr Biotechnol |
| 關鍵字: | Anti-Angiogenesis
Gene-Expression
Messenger-Rna
Up-Regulation
Calreticulin
Tumor
Cells
Growth
Amplification
Receptors |
| 日期: | 2017-09-11 |
| 上傳時間: | 2018-11-30 15:56:46 (UTC+8) |
| 出版者: | Nature Publishing Group |
| 摘要: | Neuroblastoma (NB) is a childhood cancer with a low survival rate and great metastatic potential. Vascular endothelial growth factor (VEGF), an angiogenesis factor, has been found to be involved in CRT-related neuronal differentiation of NB cells. In this study, we further confirmed the role VEGF in NB through mouse xenograft model and clinical analysis from NB patients. In xenograft experiments, CRT overexpression effectively inhibited the tumor growth. In addition, the mRNA and protein levels of VEGF and differentiation marker GAP-43 were upregulated by induced CRT expression. However, no significant correlation between the expression level of VEGF and microvessel density was observed in human NB tumors, suggesting a novel mechanism of VEGF participating in NB tumorigenesis through an angiogenesis-independent pathway. In NB patients' samples, mRNA expression levels of CRT and VEGF were positively correlated. Furthermore, positive VEGF expression by immunostaining of NB tumors was found to correlate well with histological grade of differentiation and predicted a favorable prognosis. In conclusion, our findings suggest that VEGF is a favorable prognostic factor of NB and might affect NB tumor behavior through CRT-driven neuronal differentiation rather than angiogenesis that might shed light on a novel therapeutic strategy to improve the outcome of NB. |
| 關聯: | Scientific Reports, v.7, pp.11212 |
| 顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
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