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| 標題: | Recommendation for incorporation of a different lymph node scoring system in future AJCC N category for oral cancer |
| 作者: | Lee, Ching-Chih
Su, Yu-Chieh
Hung, Shih-Kai
Chen, Po-Chun
Huang, Chung-I.
Huang, Wei-Lun
Lin, Yu-Wei
Yang, Ching-Chieh |
| 貢獻者: | Kaohsiung Vet Gen Hosp, Dept Otolaryngol Head & Neck Surg
Natl Def Med Ctr, Sch Med
Triserv Gen Hosp, Dept Otolaryngol Head & Neck Surg
Natl Yang Ming Univ, Inst Hosp & Hlth Care Adm
Natl Yang Ming Univ, Sch Med
E Da Hosp, Dept Hematol & Oncol
I Shou Univ, Sch Med, Coll Med
Buddhist DalinTzu Chi Hosp, Dept Radiat Oncol
Tzu Chi Univ, Sch Med
Pingtung Christian Hosp, Dept Radiat Oncol
E Da Canc Hosp, Dept Radiat Oncol
Kaohsiung Vet Gen Hosp, Dept Radiat Oncol
Chi Mei Med Ctr, Dept Radiat Oncol
Natl Sun Yat Sen Univ, Inst Biomed Sci
Chia Nan Univ Pharm & Sci, Dept Pharm |
| 關鍵字: | Squamous-Cell Carcinoma
Log Odds
Gastric-Cancer
Breast-Cancer
Colon-Cancer
Ratio
Cavity
Predictor
Survival
Head |
| 日期: | 2017-10-26 |
| 上傳時間: | 2018-11-30 15:56:39 (UTC+8) |
| 出版者: | Nature Publishing Group |
| 摘要: | To compare the prognostic value of 3 different lymph node scoring systems "log odds of positive nodes (LODDS), lymph node ratio (rN), and lymph node yield "in an effort to improve the staging of oral cancer. We identified 3958 oral cancer patients from Surveillance, Epidemiology, and End Results database from 2007 to 2013. In univariate analysis, LODDS, pN, rN, and lymph node yield were prognostic factors for 5-year disease-specific survival (DSS) and overall survival (OS). Multivariate analysis indicated that patients with LODDS 4 had worst 5-year DSS and OS. Stage migration occurred in pN1 and pN2 patients with LODDS 4. In pN1 patients, those with LODDS 4 had the worst 5-year DSS (41.2%) and OS (31.6%) than patients with pN1 and LODDS 2-3. In pN2 patients, those with LODDS4 had the worst 5-year DSS (34.5%) and OS (27.4%) than patients with pN2 and LODDS 2-3. The proposed staging system, which incorporates LODDS with AJCC pN, had better discriminability and prediction accuracy for predicting survival. We also noted that patients with LODDS 4 given adjuvant radiotherapy had better 5-year DSS and OS. The LODDS should be considered as a future candidate measurement for N category in oral cancer. |
| 關聯: | Scientific Reports, v.7, pp.14117 |
| 顯示於類別: | [藥學系(所)] 期刊論文
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