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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/31784

    標題: The Impact of Gastric Atrophy on the Incidence of Diabetes
    作者: Yu, Tse-Ya
    Wei, Jung-Nan
    Kuo, Chun-Heng
    Liou, Jyh-Ming
    Lin, Mao-Shin
    Shih, Shyang-Rong
    Hua, Cyue-Huei
    Hsein, Yenh-Chen
    Hsu, Ya-Wen
    Chuang, Lee-Ming
    Lee, Mei-Kuei
    Hsiao, Ching-Hsiang
    Wu, Ming-Shiang
    Li, Hung-Yuan
    貢獻者: Far Eastern Mem Hosp, Hlth Management Ctr
    Chia Nan Univ Pharm & Sci
    NewTaipei City Hosp, Dept Internal Med
    Natl Taiwan Univ Hosp, Dept Internal Med
    Natl Taiwan Univ Hosp, Yun Lin Branch, Div Clin Pathol
    關鍵字: Helicobacter-Pylori Infection
    Serum Pepsinogen-I
    Bacterial Microbiota
    Human Stomach
    I/Ii Ratio
    日期: 2017-01-03
    上傳時間: 2018-11-30 15:56:37 (UTC+8)
    出版者: Nature Publishing Group
    摘要: Gastric atrophy results in lower plasma ghrelin, higher gastrin secretion, a change in gut microbiota, and altered dietary nutrient absorption, which may be associated with the incidence of diabetes. Helicobacter pylori (H. pylori) infection is a major cause of gastric atrophy and is associated with diabetes in some reports. Since there is no study which investigates the impact of gastric atrophy on diabetes, we conduct a prospective cohort study to examine the relationship between H. pylori infection, gastric atrophy, and incident diabetes. In this study, subjects with gastric atrophy had a lower risk of incident diabetes, compared to those without gastric atrophy. The extent of gastric atrophy, measured by serum pepsinogen (PG) I/II ratio, was correlated with age, H. pylori IgG titer, HOMA2-IR, and HOMA2%B. When gastric atrophy is more extensive, presented as a lower serum PG I/II ratio, the risk of incident diabetes is lower. On the other hand, there was no significant association between H. pylori infection and the incidence of diabetes. In conclusion, the presence and the extent of gastric atrophy, but not H. pylori infection, are associated with incident diabetes. Further studies are needed to investigate the detailed mechanisms and the potential applications of the findings to guide diabetes screening and treatment strategies.
    關聯: Scientific Reports, v.7, pp.39777
    Appears in Collections:[職業安全衛生系(含防災所)] 期刊論文

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