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| 標題: | Combination of cephalosporins with vancomycin or teicoplanin enhances antibacterial effect of glycopeptides against heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) and VISA |
| 作者: | Lai, Chih-Cheng
Chen, Chi-Chung
Chuang, Yin-Ching
Tang, Hung-Jen |
| 貢獻者: | Chi Mei Med Ctr, Dept Intens Care Med
Chi Mei Med Ctr, Dept Med Res
Chi Mei Med Ctr, Dept Internal Med
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
Chi Mei Med Ctr, Dept Med |
| 關鍵字: | Minimum Inhibitory Concentration
Field Gel-Electrophoresis
Treatment Outcomes
Clinical-Outcomes
In-Vitro
Bacteremia
Infections
Strain
Susceptibility
Metaanalysis |
| 日期: | 2017-01-31 |
| 上傳時間: | 2018-11-30 15:56:30 (UTC+8) |
| 出版者: | Nature Publishing Group |
| 摘要: | Eight heterogeneous vancomycin-intermediate S. aureus (h-VISA) and seven VISA clinical isolates confirmed by the population analysis profile/area under the curve ratio (PAP/AUC) were collected. We further performed the PAP/AUC, time-killing methods and MIC tests using vancomycin/teicoplanin alone or combination with susceptible breakpoint concentrations of cefazolin, cefmetazole, cefotaxime, and cefepime for these isolates. The PAP/AUC MIC curve shifted left after addition of cephalosporins with vancomycin or teicoplanin for both h-VISA and VISA isolates. With the combination of different cephalosporins with vancomycin or teicoplanin, the AUC/Mu3 AUC ratio decreased to <0.9 for the standard Mu3 isolate which are compatible with the definition of vancomycin susceptible S. aureus. These decreases ranged between 1.81-2.02 and 2.37-2.85-fold for h-VISA treated with cephalosporins and vancomycin or teicoplanin, and 2.05-4.59, and 2.93-4,89-fold for VISA treated with cephalosporins with vancomycin or teicoplanin. As measured by time-killing assays, the combinations of different cephalosporins with vancomycin concentrations at 1/2 and 1/4 MIC, exhibited a bactericidal and bacteriostatic effect in VISA. The mean fold of MIC decline for vancomycin base combinations ranged from 1.81-3.83 and 2.71-9.33 for h-VISA and VISA, respectively. Overall, this study demonstrated the enhanced antibacterial activity of vancomycin/teicoplanin after adding cephalosporins against clinical h-VISA/VISA isolates. |
| 關聯: | Scientific Reports, v.7, pp.41758 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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