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| 標題: | The relationship of depression in asthma - chronic obstructive pulmonary disease overlap syndrome |
| 作者: | Yeh, Jun-Jun
Lin, Cheng-Li
Hsu, Wu-Huei
Kao, Chia-Hung |
| 貢獻者: | Ditmanson Med Fdn,Chia Yi Christian Hosp
Chia Nan Univ Pharm & Sci
Meiho Univ
China Med Univ Hosp, Management Off Hlth Data
China Med Univ, Coll Med
China Med Univ, Coll Med, Grad Inst Clin Med Sci
China Med Univ, Coll Med, Sch Med
China Med Univ Hosp, Div Pulm & Crit Care Med, Dept Internal Med
China Med Univ Hosp, Dept Nucl Med
China Med Univ Hosp, PET Ctr
Asia Univ, Dept Bioinformat & Med Engn |
| 關鍵字: | Quality-Of-Life
Copd-Overlap
Prevalence
Corticosteroids
Population
Anxiety
Impact |
| 日期: | 2017-12-12 |
| 上傳時間: | 2018-11-30 15:56:04 (UTC+8) |
| 出版者: | Public Library Science |
| 摘要: | Purpose To clarify the relationship between asthma - chronic obstructive pulmonary disease overlap syndrome (ACOS) and depression. Methods We identified 10,911 patients who received an ACOS diagnosis and concurrent treatment between January 2000 and December 2009. Subjects without ACOS were included in the non-ACOS cohort (n = 10,911). Cox proportional hazard regression analysis was performed to compare the risk of depression between the ACOS and non-ACOS cohorts. Results The risk of depression was higher in the ACOS cohort than in the non-ACOS cohort (adjusted hazard ratios (aHRs) = 1.67, 95% confidence interval [CI] = 1.48 - 1.88). In the ACOS cohort, the aHRs for depression were [2.44 (95% CI = 1.45 - 4.11); 2.36 (95% CI = 1.58 - 3.52)] in patients [aged 20 - 39 years; without comorbidity]. In the ACOS cohort, the aHRs for depression were 1.70 (95% CI = 1.51 - 1.93) and 1.84 (95% CI = 1.55 - 2.19) in patients without inhaled corticosteroids (ICSs) and oral steroids (OSs) use, respectively. Moreover, the aHRs for the risk of depression were 1.16 (95% CI = 0.95 - 1.41) and 1.12 (95% CI = 0.96 - 1.29) in patients with ICSs and OSs use, respectively. Conclusion The risk of depression is higher in ACOS patients, even in those without comorbidities or in young adults. The events of the depression were not significant difference in patients receiving the ICSs/OSs between the ACOS and the non-ACOS cohorts. |
| 關聯: | Plos One, v.12, n.12, e0188017 |
| 顯示於類別: | [嬰幼兒保育系] 期刊論文
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| 10.1371-journal.pone.0188017.pdf | | 1640Kb | Adobe PDF | 316 | 檢視/開啟 | | index.html | | 0Kb | HTML | 1658 | 檢視/開啟 |
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