Increased risk of chronic kidney disease in patients with rosacea: A nationwide population-based matched cohort study

doi:10.1371/journal.pone.0180446

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Title:	Increased risk of chronic kidney disease in patients with rosacea: A nationwide population-based matched cohort study
Authors:	Chiu, Hsien-Yi Huang, Wen-Yen Ho, Chung-Han Wang, Jhi-Joung Lin, Sung-Jan Hsu, Ya-Wen Chen, Ping-Jen
Contributors:	Natl Taiwan Univ, Coll Med, Inst Biomed Engn Natl Taiwan Univ, Coll Engn Natl Taiwan Univ Hosp, Hsin Chu Branch, Dept Dermatol Natl Taiwan Univ Hosp, Dept Dermatol Natl Taiwan Univ, Coll Med Chi Mei Med Ctr, Dept Med Res Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm Chia Nan Univ Pharm & Sci, Dept Pharm Natl Taiwan Univ, Res Ctr Dev Biol & Regenerat Med Chi Mei Med Ctr, Dept Geriatr & Gerontol Kaohsiung Med Univ,Kaohsiung Med Univ Hosp, Dept Family Med
Keywords:	Metabolic Syndrome Cardiovascular-Disease Oxidative Stress Inflammation Mortality Association Activation Psoriasis Severity Taiwan
Date:	2017-10-02
Issue Date:	2018-11-30 15:56:02 (UTC+8)
Publisher:	Public Library Science
Abstract:	Background Rosacea is a chronic inflammatory skin disorder. Inflammation and oxidative stress are involved in the etiopathogenesis of rosacea and chronic kidney disease (CKD). This study aimed to investigate the association between rosacea and CKD. Methods This population-based cohort study identified 277 patients with rosacea in the Taiwan National Health Insurance Research Database during 2001-2005. These patients were matched for age, sex, and comorbidities with 2216 patients without rosacea. All subjects were individually followed-up for 8-12 years to identify those who subsequently developed CKD Results The incidence rates of CKD per 1000 person-years were 16.02 in patients with rosacea and 10.63 in the non-rosacea reference population. After adjusting for other covariates and considering the competing risk of mortality, patients with rosacea remained at increased risk of CKD (adjusted sub-distribution hazard ratio (aSD-HR) 2.00; 95% confidence interval (CI) 1.05-3.82). The aSD-HRs (95% CI) for CKD were 1.82 (0.83-4.00) and 2.53 (1.11-5.75) for patients with mild and moderate-to-severe rosacea, respectively. Conclusions Rosacea is an independent risk factor for CKD. High rosacea severity and old age further increased CKD risk in patients with rosacea. Careful monitoring for CKD development should be included as part of integrated care for patients with rosacea.
Relation:	Plos One, v.12, n.10, e0180446
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles [Dept. of Hospital and Health (including master's program)] Periodical Articles

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