Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/31763
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 18057/20255 (89%)
造访人次 : 1326579      在线人数 : 921
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/31763


    標題: Protective effect of HDL on NADPH oxidase-derived super oxide anion mediates hypoxia-induced cardiomyocyte apoptosis
    作者: Wen, Su-Ying
    Tamilselvi, Shanmugam
    Shen, Chia-Yao
    Day, Cecilia Hsuan
    Chun, Li-Chin
    Cheng, Li-Yi
    Ou, Hsiu-Chung
    Chen, Ray-Jade
    Viswanadha, Vijaya Padma
    Kuo, Wei-Wen
    Huang, Chih-Yang
    貢獻者: Taipei City Hosp, Renai Branch, Dept Dermatol
    Mackay Jr Coll Med Nursing & Management, Ctr Gen Educ
    China Med Univ, Grad Inst Basic Med Sci
    MeiHo Univ, Dept Nursing
    Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
    Asia Univ, Dept Biol Sci & Technol
    Taipei Med Univ, Dept Surg, Sch Med, Coll Med
    Bharathiar Univ, Dept Biotechnol, Coimbatore
    China Med Univ, Dept Biol Sci & Technol
    China Med Univ, Grad Inst Chinese Med Sci
    關鍵字: Serum Response Factor
    N-Terminal Kinases
    Neutrophil Respiratory Burst
    Activated Protein-Kinases
    Oxidative Stress
    Heart-Failure
    Cardiovascular-Disease
    Gene-Expression
    Hif-1-Alpha
    Angiogenesis
    日期: 2017-06-15
    上傳時間: 2018-11-30 15:55:47 (UTC+8)
    出版者: Public Library Science
    摘要: Cardiovascular diseases are the leading cause of death of death in Taiwan. Atherosclerosis can lead to serious problems, including heart attack, stroke, or even death. Coronary heart disease (CHD) occurs when plaque builds up in the coronary arteries to cause the ischemic heart disease which will enhance myocardial remodeling and also induce myocardial hypoxia. High density lipoprotein (HDL) has been proposed to have cardio-protective effects. Under hypoxic conditions (1%O-2 for 24hr), in H9c2 cells, reactive oxygen species (ROS) is induced which leads to cardiomyocyte apoptosis and cardiac dysfunction. Therefore, the present study described the protective effect of HDL on hypoxia-induced cardiomyocyte damage. We investigated the NADPH oxidase-produced ROS-related signaling pathways and apoptosis in cardiomyocytes under hypoxia conditions. Results showed that the ROS mediated cardiac damage might occur via AT1 and PKC activation. Furthermore, hypoxia downregulated the survival protein (p-AKT(ser473)) and anti-apoptotic protein (BCL2), whereas pro-apoptotic protein, Bax and caspase 3 were upregulated. These detrimental effects by ROS and apoptosis were prevented by HDL pretreatment. Our findings revealed the underlying molecular mechanism by which HDL suppresses the hypoxia-induced cardiomyocyte dysfunction. Further, we elucidated the role of HDL on preventing hypoxia induced cardiomyocyte apoptosis is mediated through the inhibition of NADPH oxidase-derived ROS.
    關聯: Plos One, v.12, n.6, e0179492
    显示于类别:[醫務管理系(所)] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    10.1371-journal.pone.0179492.pdf9348KbAdobe PDF0检视/开启
    index.html0KbHTML1279检视/开启


    在CNU IR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈