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| 標題: | Hyperlipidemia and statins use for the risk of new-onset anxiety/depression in patients with head and neck cancer: A population-based study |
| 作者: | Huang, Chung-I
Lin, Li-Ching
Tien, Hung-Cheng
Que, Jenny
Ting, Wei Chen
Chen, Po-Chun
Wu, Hsin-Min
Ho, Chung-Han
Wang, Jhi-Joung
Wang, Ren-Hong
Yang, Ching-Chieh |
| 貢獻者: | E Da Canc Hosp, Dept Radiat Oncol
Chi Mei Med Ctr, Dept Radiat Oncol
Minist Hlth & Welf, Pingtung Hosp, Dept Psychiat
Pingtung Christian Hosp, Dept Radiat Oncol
Natl Cheng Kung Univ, Dept Publ Hlth, Coll Med,Natl Cheng Kung Univ Hosp
Chi Mei Med Ctr, Dept Med Res
Chia Nan Univ Pharm & Sci, Dept Pharm
Chi Mei Med Ctr, Dept Clin Pathol
Chung Hwa Univ Med Technol, Dept Med Lab Sci & Biotechnol
Natl Sun Yat Sen Univ, Inst Biomed Sci
Chia Nan Univ Pharm & Sci, Dept Biotechnol |
| 關鍵字: | Quality-Of-Life
Cardiovascular-Disease
Metabolic Syndrome
Depression
Anxiety
Inflammation
Metaanalysis
Mortality
Symptoms |
| 日期: | 2017-03-31 |
| 上傳時間: | 2018-11-30 15:55:40 (UTC+8) |
| 出版者: | Public Library Science |
| 摘要: | Objective Anxiety/depression is common among patients with head and neck cancer (HNC), and can negatively affect treatment compliance and outcome. The aim of this study was to assess the association between hyperlipidemia and the risk of new-onset anxiety/depression after the diagnosis of HNC and the influence of administering statins. Methods A matched longitudinal cohort study of 1632 subjects (408 HNC patients with preexisting hyperlipidemia and 1224 age- and sex-matched HNC patients without hyperlipidemia) was included and analyzed by using data from Taiwan's National Health Insurance Research Database from January 1996 to December 2012. The incidence and hazard ratios (HRs) for the development of new-onset anxiety/depression were examined between the two groups. Cox proportional hazard regression was applied to estimate the relative risks of anxiety/depressive disorders adjusted for potential confounding factors. To estimate the risks of anxiety/depression in different sub-groups, a stratified analysis was also used. Results HNC patients with preexisting hyperlipidemia had a higher risk for comorbidities such as hypertension, diabetes mellitus, and cardiovascular disease (P <0.001). The incidence rate of anxiety/depression in the HNC patients with preexisting hyperlipidemia was also significantly higher than that among patients without hyperlipidemia (10.78% vs 7.27%, respectively; P = 0.03). A Cox regression model revealed that preexisting hyperlipidemia was an independent risk factor for anxiety/depression (aHR, 1.96; 95% CI, 1.30-2.94). Statins use was protective against anxiety/depression among HNC patients with hyperlipidemia ( aHR, 0.85; 95% CI, 0.46-1.57), especially for individuals older than 65 years and for females. Conclusions Preexisting hyperlipidemia was associated with increased risk of new-onset anxiety/depression in the HNC patients. Statins use for HNC patients with hyperlipidemia could decrease the risk of anxiety/depression, especially for those older than 65 years and for female patients. |
| 關聯: | Plos One, v.12, n.3, e0174574 |
| 顯示於類別: | [藥學系(所)] 期刊論文
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