Cryptotanshinone Inhibits STAT3 Signaling to Alleviate Cardiac Fibrosis in Type 1-like Diabetic Rats

doi:10.1002/ptr.5777

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/31755

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Title:	Cryptotanshinone Inhibits STAT3 Signaling to Alleviate Cardiac Fibrosis in Type 1-like Diabetic Rats
Authors:	Lo, Shih-Hsiang Hsu, Chao-Tien Niu, Ho-Shan Niu, Chiang-Shan Cheng, Juei-Tang Chen, Zhih-Cherng
Contributors:	Taipei City Hosp, Zhongxing Branch, Dept Internal Med Tzu Chi Univ Sci & Technol, Dept Nursing I Shou Univ, E DA Hosp, Dept Pathol Chi Mei Med Ctr, Dept Cardiol Chi Mei Med Ctr, Dept Med Res Chang Jung Christian Univ, Inst Med Sci Chia Nan Univ Pharm & Sci, Dept Pharm
Keywords:	cryptotanshinone STAT3 type 1 diabetes cardiomyopathy cardiac fibrosis STZ rats
Date:	2017-04
Issue Date:	2018-11-30 15:55:28 (UTC+8)
Publisher:	Wiley
Abstract:	Cryptotanshinone is an active principal ingredient isolated from Salvia miltiorrhiza (Danshen), a medicinal plant used in China to treat cardiac disorders. The objective of this study was to investigate the effect of cryptotanshinone on myocardial fibrosis in diabetic rats. In streptozotocin-induced type 1 diabetic model hyperglycemic rats (STZ-treated rats), fasting blood glucose levels and heart weight/body weight ratio were markedly increased but both were not modified by cryptotanshinone. Additionally, cardiac performance in catheterized STZ-treated rats was improved. The histological results from Masson staining showed that cryptotanshinone attenuated cardiac fibrosis in STZ-treated rats. Moreover, both the mRNA and protein levels of the signal transducer and activator of transcription 3 (STAT3), matrix metalloproteinase-9, and connective tissue growth factor were reduced by cryptotanshinone in high glucose-cultured cardiomyocytes, similar to the reductions observed in the hearts of STZ-treated rats. In conclusion, while STAT3 regulates matrix metalloproteinase-9 and connective tissue growth factor expression in diabetic rats with cardiac fibrosis, cryptotanshinone inhibited fibrosis to improve cardiac function by suppressing the STAT3 pathway. Cryptotanshinone is suitable as an alternative remedy for therapy of cardiac fibrosis. Copyright (c) 2017 John Wiley & Sons, Ltd.
Relation:	Phytotherapy Research, v.31, n.4, pp.638-646
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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