Increased risk for diabetes mellitus in patients with carbon monoxide poisoning

doi:10.18632/oncotarget.18887

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/31747

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/31747

Title:	Increased risk for diabetes mellitus in patients with carbon monoxide poisoning
Authors:	Huang, Chien-Cheng Ho, Chung-Han Chen, Yi-Chen Lin, Hung-Jung Hsu, Chien-Chin Wang, Jhi-Joung Su, Shih-Bin Guo, How-Ran
Contributors:	Chi Mei Med Ctr, Dept Emergency Med Natl Cheng Kung Univ, Dept Environm & Occupat Hlth Southern Taiwan Univ Sci & Technol, Bachelor Program Senior Serv Chi Mei Med Ctr, Dept Geriatr & Gerontol Chi Mei Med Ctr, Dept Occupat Med Chi Mei Med Ctr, Dept Med Res Chia Nan Univ Pharm & Sci, Dept Pharm Southern Taiwan Univ Sci & Technol, Dept Biotechnol Taipei Med Univ, Dept Emergency Med Southern Taiwan Univ Sci & Technol, Dept Leisure Recreat & Tourism Management Natl Cheng Kung Univ Hosp, Dept Occupat & Environm Med
Keywords:	brain carbon monoxide endocrine diabetes mellitus poisoning
Date:	2017-09-08
Issue Date:	2018-11-30 15:55:11 (UTC+8)
Publisher:	Impact Journals Llc
Abstract:	Carbon monoxide poisoning (COP) causes hypoxic injury and inflammatory and immunological reactions in the brain and local organs including the pancreas. Therefore, it is plausible that COP may increase the risk for developing diabetes mellitus (DM), but studies on this possible association are limited. We conducted a nationwide study in Taiwan to fill the data gap. We used the Nationwide Poisoning Database and the Longitudinal Health Insurance Database 2000 to identify all COP patients diagnosed between 1999 and 2012 (the study cohort) and then construct a comparison cohort of patients without COP through matching at 1: 3 by the index date and age. The risk for DM between the two cohorts was compared by following up until 2013. We also investigated the independent predictors for DM in all the patients. During the study period, 22,308 COP patients were identified, and 66,924 non-COP patients were included in the comparison cohort accordingly. Patients with COP had an increased risk for DM with an adjusted hazard ratio (AHR) of 1.92 (95% confidence interval [CI]: 1.79-2.06) after adjusting for age, sex, comorbidities, and monthly income, especially in the subgroups of age <35 years, age >= 65 years, female sex, and comorbidities with congestive heart failure, hyperthyroidism, and polycystic ovary syndrome. Cox proportional hazard regression analysis showed that the increased risk for DM was highest in the first month after COP (AHR=3.38; 95% CI: 2.29-4.99) and lasted even after 4 years (AHR=1.82; 95% CI: 1.62-2.04). We found that COP, older age, male sex, hypertension, hyperlipidemia, hyperuricemia, and low monthly income were independent predictors for DM. Intervention studies are needed to validate the results and delineate the detailed mechanisms.
Relation:	Oncotarget, v.8, n.38, pp.63680-63690
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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