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| 標題: | IL-8 promotes inflammatory mediators and stimulates activation of p38 MAPK/ERK-NF-kappa B pathway and reduction of JNK in HNSCC |
| 作者: | Chan, Leong-Perng
Liu, Cheng
Chiang, Feng-Yu
Wang, Ling-Feng
Lee, Ka-Wo
Chen, Wan-Ting
Kuo, Po-Lin
Liang, Chia-Hua |
| 貢獻者: | Kaohsiung Med Univ, Grad Inst Clin Med
Kaohsiung Med Univ,Kaohsiung Med Univ Hosp, Dept Otolaryngol Head & Neck Surg
Chi Mei Med Ctr, Div Plast Surg
Chi Mei Med Ctr, HBOT Ctr
Southern Taiwan Univ Sci & Technol, Dept Elect Engn
Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
Chia Nan Univ Pharm & Sci, Inst Cosmet Sci
Natl Sun Yat Sen Univ, Inst Med Sci & Technol |
| 關鍵字: | HNSCC
IL-8
inflammation
MAPK |
| 日期: | 2017-08-22 |
| 上傳時間: | 2018-11-30 15:55:09 (UTC+8) |
| 出版者: | Impact Journals Llc |
| 摘要: | This investigation identifies interleukin 8 (IL-8) as the main inflammatory mediator in head and neck squamous cell carcinoma (HNSCC). The expressions of chemokines of IL-8, IL-1 beta and IL-6 and the cytokines of tumor necrosis factor-alpha (TNF-alpha) were higher in HNSCC patient tissues than in non-cancerous matched tissues (NCMT) whereas the expression of IL-10 was lower. IL-8 is most highly expressed in the tissues of patients with HNSCC. Treatment of HNSCC cells with IL-8 increased the secretion of IL-1 beta, IL-6 and TNF-alpha and reduced IL-10 expression; the increase in the expression of IL-1 beta was particularly considerable. IL-8 silencing by siRNA reduced IL-1 beta expression in HNSCC cells, suggesting that IL-8 as a main inflammatory mediator improved IL-1 beta expression in HNSCC. The expressions of p-p38 mitogen-activated protein kinases (MAPK) and p-extracellular signal regulated kinase (p-ERK) were higher and that of p-c-Jun-NH2-terminal kinase (p-JNK) was lower in HNSCC patient tissues than in NCMT. IL-8 treatment induced p-p38 MAPK and p-ERK expression, but reduced p-JNK expressions in HNSCC cells. IL-8 siRNA suppressed p38 MAPK and ERK but increased JNK expression in HNSCC cells. Exposure of SCC25 cells to IL-8, increased the expressions of p-I kappa B-alpha and nuclear factor (NF)-kappa B, suggesting that IL-8 regulates inflammatory response by modulating the MAPK and NF-kappa B pathway in HNSCC cells. IL-8 promotes the migration of SCC25 cells and increases matrix metalloproteinase-2 (MMP-2) and MMP-9 expressions. These results reveal that IL-8 is the major stimulus of inflammatory mediation in HNSCC progression and migration by activating the p38 MAPK/ERK-NF-kappa B pathway and reducing JNK. |
| 關聯: | Oncotarget, v.8, n.34, pp.56375-56388 |
| 顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
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