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https://ir.cnu.edu.tw/handle/310902800/31745
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| 標題: | OSU-A9 inhibits pancreatic cancer cell lines by modulating p38-JAK-STAT3 signaling |
| 作者: | Tsai, Wan-Chi
Bai, Li-Yuan
Chen, Yi-Jin
Chu, Po-Chen
Hsu, Ya-Wen
Sargeant, Aaron M.
Weng, Jing-Ru |
| 貢獻者: | Kaohsiung Med Univ, Dept Med Lab Sci & Biotechnol
Kaohsiung Med Univ, Ctr Infect Dis & Canc Res
China Med Univ, Coll Med
China Med Univ Hosp, Div Hematol & Oncol, Dept Internal Med
Acad Sinica, Inst Biol Chem
Natl Cheng Kung Univ, Inst Basic Med Sci, Coll Med
Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
Charles River Labs, Safety Assessment
Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources |
| 關鍵字: | OSU-A9
pancreatic cancer
p38
JAK
STAT3 |
| 日期: | 2017-04-25 |
| 上傳時間: | 2018-11-30 15:55:06 (UTC+8) |
| 出版者: | Impact Journals Llc |
| 摘要: | Pancreatic cancer is an aggressive malignancy that is the fourth leading cause of death worldwide. Since there is a dire need for novel and effective therapies to improve the poor survival rates of advanced pancreatic cancer patients, we analyzed the antitumor effects of OSU-A9, an indole-3-carbinol derivative, on pancreatic cancer cell lines in vitro and in vivo. OSU-A9 exhibited a stronger antitumor effect than gemcitabine on two pancreatic cancer cell lines, including gemcitabine-resistant PANC-1 cells. OSU-A9 treatment induced apoptosis, the down-regulation of Akt phosphorylation, up-regulation of p38 phosphorylation and decreased phosphorylation of JAK and STAT3. Cell migration and invasiveness assays showed that OSU-A9 reduced cancer cell aggressiveness and inhibited BxPC-3 xenograft growth in nude mice. These results suggest that OSU-A9 modulates the p38-JAK-STAT3 signaling module, thereby inducing cytotoxicity in pancreatic cancer cells. Continued evaluation of OSU-A9 as a potential therapeutic agent for pancreatic cancer thus appears warrented. |
| 關聯: | Oncotarget, v.8, n.17, pp.29233-29246 |
| 顯示於類別: | [醫務管理系(所)] 期刊論文
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