English  |  正體中文  |  简体中文  |  Items with full text/Total items : 18076/20274 (89%)
Visitors : 4818666      Online Users : 932
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/31735


    標題: Infection-related hospitalization and risk of end-stage renal disease in patients with systemic lupus erythematosus: a nationwide population-based study
    作者: Lin, Chien-Hung
    Hung, Peir-Haur
    Hu, Hsiao-Yun
    Chen, Yann-Jang
    Guo, How-Ran
    Hung, Kuan-Yu
    貢獻者: Natl Yang Ming Univ, Inst Clin Med
    Taipei City Hosp, Zhongxing Branch, Dept Pediat
    Ditmanson Med Fdn, Dept Internal Med,Chia Yi Christian Hosp
    Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth
    Taipei City Hosp, Dept Educ & Res
    Natl Cheng Kung Univ, Dept Environm & Occupat Hlth, Coll Med
    Natl Cheng Kung Univ Hosp, Dept Occupat & Environm Med
    Natl Taiwan Univ Hosp, Dept Internal Med, Hsin Chu Branch
    關鍵字: end-stage renal disease
    hospitalization
    infection
    National Health Insurance
    systemic lupus erythematosus
    日期: 2017-10
    上傳時間: 2018-11-30 15:54:44 (UTC+8)
    出版者: Oxford Univ Press
    摘要: Background. Infections are a major cause of morbidity in patients with systemic lupus erythematosus (SLE), and may lead to death. No nationally representative study of patients with SLE has examined the rates of infection-related hospitalization and the risk of end-stage renal disease (ESRD). Methods. We conducted a nationwide cohort study of 7326 patients with newly diagnosed SLE and no history of ESRD. All data were from Taiwan's National Health Insurance claims database for the period 2000-11. Results. Among all SLE patients, 316 (4.3%) developed ESRD (mean follow-up time: 8.1 years). Multivariate Cox regression analysis indicated that the risk of ESRD increased with the number of infection-related hospitalizations. For patients with three or more infection-related admissions, the hazard ratio (HR) for ESRD was 5.08 [95% confidence interval (CI): 3.74-6.90] relative to those with no infection-related admission. Analysis by type of infection indicated that bacteremia patients had the greatest risk for ESRD (HR: 4.82; 95% CI: 3.40-6.85). Analysis of age of SLE onset indicated that patients with juvenile-onset (< 18 years) and three or more infection-related hospitalizations had a greatly increased risk for ESRD (HR: 14.49; 95% CI: 5.34-39.33). Conclusions. Infection-related hospitalizations are associated with a significantly increased risk of ESRD in patients with SLE, especially those with juvenile-onset SLE. Among patients with different types of infectious diseases, those with bacteremia were more likely to develop ESRD.
    關聯: Nephrology Dialysis Transplantation, v.32, n.10, pp.1683-1690
    Appears in Collections:[生活保健科技系] 期刊論文

    Files in This Item:

    File Description SizeFormat
    10.1093-ndt-gfw407.pdf793KbAdobe PDF0View/Open
    index.html0KbHTML1218View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback