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https://ir.cnu.edu.tw/handle/310902800/31735
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標題: | Infection-related hospitalization and risk of end-stage renal disease in patients with systemic lupus erythematosus: a nationwide population-based study |
作者: | Lin, Chien-Hung Hung, Peir-Haur Hu, Hsiao-Yun Chen, Yann-Jang Guo, How-Ran Hung, Kuan-Yu |
貢獻者: | Natl Yang Ming Univ, Inst Clin Med Taipei City Hosp, Zhongxing Branch, Dept Pediat Ditmanson Med Fdn, Dept Internal Med,Chia Yi Christian Hosp Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth Taipei City Hosp, Dept Educ & Res Natl Cheng Kung Univ, Dept Environm & Occupat Hlth, Coll Med Natl Cheng Kung Univ Hosp, Dept Occupat & Environm Med Natl Taiwan Univ Hosp, Dept Internal Med, Hsin Chu Branch |
關鍵字: | end-stage renal disease hospitalization infection National Health Insurance systemic lupus erythematosus |
日期: | 2017-10 |
上傳時間: | 2018-11-30 15:54:44 (UTC+8) |
出版者: | Oxford Univ Press |
摘要: | Background. Infections are a major cause of morbidity in patients with systemic lupus erythematosus (SLE), and may lead to death. No nationally representative study of patients with SLE has examined the rates of infection-related hospitalization and the risk of end-stage renal disease (ESRD). Methods. We conducted a nationwide cohort study of 7326 patients with newly diagnosed SLE and no history of ESRD. All data were from Taiwan's National Health Insurance claims database for the period 2000-11. Results. Among all SLE patients, 316 (4.3%) developed ESRD (mean follow-up time: 8.1 years). Multivariate Cox regression analysis indicated that the risk of ESRD increased with the number of infection-related hospitalizations. For patients with three or more infection-related admissions, the hazard ratio (HR) for ESRD was 5.08 [95% confidence interval (CI): 3.74-6.90] relative to those with no infection-related admission. Analysis by type of infection indicated that bacteremia patients had the greatest risk for ESRD (HR: 4.82; 95% CI: 3.40-6.85). Analysis of age of SLE onset indicated that patients with juvenile-onset (< 18 years) and three or more infection-related hospitalizations had a greatly increased risk for ESRD (HR: 14.49; 95% CI: 5.34-39.33). Conclusions. Infection-related hospitalizations are associated with a significantly increased risk of ESRD in patients with SLE, especially those with juvenile-onset SLE. Among patients with different types of infectious diseases, those with bacteremia were more likely to develop ESRD. |
關聯: | Nephrology Dialysis Transplantation, v.32, n.10, pp.1683-1690 |
Appears in Collections: | [生活保健科技系] 期刊論文
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