High expression of mitochondrial intermembrane chaperone TIMM9 represents a negative prognostic marker in gastric cancer

doi:10.1016/j.jfma.2016.08.007

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標題:	High expression of mitochondrial intermembrane chaperone TIMM9 represents a negative prognostic marker in gastric cancer
作者:	Lin, Chih-Chan Fang, Chia-Lang Sun, Ding-Ping Hseu, You-Cheng Uen, Yih-Huei Lin, Kai-Yuan Lin, Yung-Chang
貢獻者:	Chi Mei Med Ctr, Dept Med Res Natl Chung Hsing Univ, Dept Vet Med Taipei Med Univ, Sch Med, Dept Pathol, Coll Med Taipei Med Univ, Wan Fang Hosp, Dept Pathol Chi Mei Med Ctr, Dept Surg Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol China Med Univ, Dept Cosmeceut Asia Univ, Dept Hlth & Nutr Biotechnol Chi Mei Hosp Chiali, Superintendents Off Chia Nan Univ Pharm & Sci, Dept Biotechnol
關鍵字:	gastric cancer prognostic marker survival
日期:	2017-06
上傳時間:	2018-11-30 15:54:01 (UTC+8)
出版者:	Elsevier Taiwan
摘要:	Background/Purpose: Gastric cancer (GC) is one of the most common malignant cancers worldwide. However, little is known about the molecular process underlying this disease and its progression. This study investigated correlations between the expression of a mitochondrial inner membrane protein translocase of inner mitochondrial membrane 9 homolog (TIMM9) and various clinicopathologic parameters as well as patients' survival. Methods: Gastric tissue samples were obtained from 140 patients with GC and expression levels of TIMM9 were analyzed through immunohistochemistry. Paired t tests were used to analyze the differences in the expression levels of TIMM9 in both tumor and nontumor tissues for each patient. Two-tailed chi(2) tests were performed to determine whether the differences in TIMM9 expression and clinicopathologic parameters were significant. Time-to-event endpoints for clinicopathologic parameters were plotted using the Kaplane-Meier method, and statistical significance was determined using univariate log-rank tests. Cox proportional hazard model was used for multivariate analysis to determine the independence of prognostic effects of TIMM9 expression. Results: A borderline association was found between overexpression of TIMM9 and vascular invasion (p = 0.0887). Patients with high expression levels of TIMM9 achieved a significantly lower disease-free survival rate compared with those with low expression levels (p = 0.005). Multivariate Cox regression analysis showed that overexpression of TIMM9 was an independent prognostic marker for GC (p = 0.011). Conclusion: Overexpression of TIMM9 can be used as a marker to predict the outcome of patients with GC. Copyright (C) 2016, Formosan Medical Association. Published by Elsevier Taiwan LLC.
關聯:	Journal of The Formosan Medical Association, v.116, n.6, pp.476-483
顯示於類別:	[ 食品科技系 ] 期刊論文

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