Antihypertensive effects of Ocimum gratissimum extract: Angiotensin-converting enzyme inhibitor in vitro and in vivo investigation

doi:10.1016/j.jff.2017.05.033

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 保健營養系(所) > 期刊論文 > Item 310902800/31699

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標題:	Antihypertensive effects of Ocimum gratissimum extract: Angiotensin-converting enzyme inhibitor in vitro and in vivo investigation
作者:	Shaw, Huey-Mei Wu, Jhih-Ling Wang, Ming-Shyong
貢獻者:	Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
關鍵字:	Ocimum gratissimum (OG) Spontaneously hypertensive rats (SHRs) Angiotensin-converting enzyme (ACE) ACE inhibitor Rutin
日期:	2017-08
上傳時間:	2018-11-30 15:53:22 (UTC+8)
出版者:	Elsevier Science Bv
摘要:	This study aimed to examine whether Ocimum gratissimum (OG) has the Angiotensin-converting enzyme (ACE) inhibitory activity in vitro and in spontaneously hypertensive rats (SHRs). OG water extract exhibited an in vitro ACE-inhibition activity, with the 50% inhibition concentration (IC50) value being 56.3 mu g/mL, which is higher than rutin's 43.08 mu g/mL. The main phenolic compound found in OG extract was rutin, according to the HPLC fractionation profile. The anti-hypertension effect in vivo was tested with SHRs. SHRs were fed orally with a distilled water, 100 or 500 mg/kg BW OG extract for 8 weeks. Systolic blood pressure, ACE levels in plasma and lung, and plasma endothelin-1 were significantly lower in the 500 mg/kg OG group compared with the SHRs group. These results suggested that OG extract has the ACE inhibition activity in vitro and also in SHRs, which may be due to its main component of phenolic compound, rutin. (C) 2017 Elsevier Ltd. All rights reserved.
關聯:	Journal of Functional Foods, v.35, pp.68-73
显示于类别:	[保健營養系(所) ] 期刊論文

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