Autophagy-inducing effect of pterostilbene: A prospective therapeutic/preventive option for skin diseases

doi:10.1016/j.jfda.2016.10.022

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標題:	Autophagy-inducing effect of pterostilbene: A prospective therapeutic/preventive option for skin diseases
作者:	Chen, Rong-Jane Lee, Yu-Hsuan Yeh, Ya-Ling Wu, Wun-Syuan Ho, Chi-Tang Li, Chia-Yi Wang, Bour-Jr Wang, Ying-Jan
貢獻者:	Natl Cheng Kung Univ, Dept Environm & Occupat Hlth, Coll Med Rutgers State Univ, Dept Food Sci Robert Thirsk High Sch, Calgary Natl Cheng Kung Univ Hosp, Dept Occupat & Environm Med Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Chia Nan Univ Pharm & Sci, Inst Cosmet Sci Asia Univ, Dept Biomed Informat China Med Univ,China Med Univ Hosp, Dept Med Res Taipei Med Univ, Grad Inst Clin Med
關鍵字:	autophagy inflammation pterostilbene skin disorders
日期:	2017-01
上傳時間:	2018-11-30 15:53:16 (UTC+8)
出版者:	Food & Drug Adminstration
摘要:	Pterostilbene is a naturally occurring analog of resveratrol with many health benefits. These health benefits are associated with its antioxidant activity, anti-inflammatory effects, and chemopreventive effects attributed to its unique structure. The skin cancer chemopreventive potential of pterostilbene is supported by a variety of mechanistic studies confirming the anti-inflammatory effects in skin cancer models. Molecular biological studies have identified that pterostilbene targets pleotropic signaling pathways, including those involved in mitogenesis, cell cycle regulation, and apoptosis. Recently, pterostilbene has been reported to induce autophagy in cancer and normal cells. Through autophagy induction, the inflammatory-related skin diseases can be attenuated. This finding suggests the potential use of pterostilbene in the treatment and prevention of skin disorders via alleviating inflammatory responses by autophagy induction. This review summarizes the protective and therapeutic benefits of pterostilbene in skin diseases from the viewpoint of its antioxidant, anti-inflammatory, and autophagy-inducing effects. Novel underlying mechanisms regarding these effects are discussed. We proposed that pterostilbene, a promising natural product, can be used as a preventive and therapeutic agent for inflammation-related skin disorders through induction of autophagy. Copyright (C) 2016, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.
關聯:	Journal of Food and Drug Analysis, v.25, n.1, pp.125-133
顯示於類別:	[化妝品應用與管理系(所)] 期刊論文

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