The nonbiodegradable pollutants and high-strength nitrogen-and sulfur-containing compounds found in the wastewater from the thin-film transistor liquid-crystal display (TFT-LCD) screen industry are difficult to degrade. An electro-Fenton procedure has been developed to increase the efficiency of the ferric reduction. The organic compounds are ionized or oxidized by direct electrolysis on the anode in the electrolytic cell of the electro-Fenton process. The effects of operating parameters such as concentrations of Fe2+ and H2O2, pH, and current density on chemical oxygen demand (COD) removal were determined. The degradation of the TFT-LCD wastewater was faster by the electro-Fenton process than the conventional Fenton process. The highest COD removal efficiency was 100% at 120 min; pH = 4; [Fe2+] = 3.5 mM; [H2O2] = 285 mM; and 1.5 A/dm(2) of current density. The energy cost of the electro-Fenton process for treating TFT-LCD wastewater was approximately US$0.1/L. (C) 2017 American Society of Civil Engineers.