Cisplatin Nephrotoxicity Might Have a Sex Difference. An analysis Based on Women's Sex Hormone Changes

doi:10.7150/jca.20083

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/31690

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Title:	Cisplatin Nephrotoxicity Might Have a Sex Difference. An analysis Based on Women's Sex Hormone Changes
Authors:	Chen, Wei-Yu Hsiao, Ching-Hsing Chen, Yi-Chen Ho, Chung-Han Wang, Jhi-Joung Hsing, Chung-Hsi Wang, Hsien-Yi Kan, Wei-Chih Wu, Chia-Chun
Contributors:	Chi Mei Med Ctr, Dept Hematol & Oncol Chi Mei Hosp, Dept Ophthalmol Chi Mei Med Ctr, Dept Med Res Chia Nan Univ Pharm & Sci, Dept Pharm Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm Chi Mei Med Ctr, Dept Med Res Chi Mei Med Ctr, Dept Anesthesiol Taipei Med Univ, Dept Anesthesiol, Coll Med Chi Mei Med Ctr, Dept Nephrol, Dept Internal Med Chia Nan Univ Pharm & Sci, Dept Sports Management, Coll Leisure & Recreat Management Chung Hwa Univ Med Technol, Dept Biol Sci & Technol
Keywords:	cisplatin nephrotoxicity sex difference chronic kidney disease acute kidney disease
Date:	2017
Issue Date:	2018-11-30 15:53:01 (UTC+8)
Publisher:	Ivyspring Int Publ
Abstract:	Background: A sex difference in cisplatin-induced nephrotoxicity (CIN) has been reported in human and animal studies. We examined in humans whether it is associated with sex-hormone changes. Methods: In this retrospective nationwide cohort study, we used Taiwan's National Health Insurance Research Database (NHIRD) to identify patients with a history of malignancy and cisplatin treatment. Patients diagnosed with kidney disease before cisplatin treatment and those with sex-organ malignancies were excluded. A diagnosis of kidney disease within 90 days after the first administration of cisplatin was the study outcome. Risk factors were estimated using a Cox regression model. Subgroup analyses were performed based on different women's estrogen levels in phases of childbearing, perimenopause, and postmenopause. Results: A retrospective analysis of the records of 3973 men (mean age: 56.15 +/- 12.85 years) and 1154 women (mean age: 56.31 +/- 12.40 years) showed that 1468 (36.95%) men and 451 (39.08%) women had a new diagnosis of kidney disease. The risk factors were being > 55 years old, a high comorbidity score, and a history of aminoglycoside treatment. Only postmenopausal women had a significantly higher risk of kidney injury (hazard ratio: 1.28; 95% CI: 1.02-1.61) than did men. Conclusions: Perimenopausal women have a significantly higher risk of CIN than do men, which might be explained by women's higher levels of estrogen. Additional studies on the underlying mechanisms of the sex difference of CIN are needed.
Relation:	Journal of Cancer, v.8, n.19, pp.3939-3944
Appears in Collections:	[Dept. of Hospital and Health (including master's program)] Periodical Articles [Dept. of Pharmacy] Periodical Articles

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