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https://ir.cnu.edu.tw/handle/310902800/31688
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| 標題: | Overexpression of Transcobalamin 1 is an Independent Negative Prognosticator in Rectal Cancers Receiving Concurrent Chemoradiotherapy |
| 作者: | Lee, Yi-Ying
Wei, Yu-Ching
Tian, Yu-Feng
Sun, Ding-Ping
Sheu, Ming-Jen
Yang, Ching-Chieh
Lin, Li-Ching
Lin, Chen-Yi
Hsing, Chung-Hsi
Li, Wan-Shan
Li, Chien-Feng
Hsieh, Pei-Ling
Lin, Ching-Yih |
| 貢獻者: | Chi Mei Med Ctr, Dept Pathol
Natl Sun Yat Sen Univ, Inst Biomed Sci
Kaohsiung Municipal Tatung Hosp, Dept Pathol
Chi Mei Med Ctr, Dept Surg, Div Gen Surg
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
Chia Nan Univ Pharm & Sci, Dept Pharm
Chi Mei Med Ctr, Dept Internal Med, Div Gastroenterol & Hepatol
Chi Mei Med Ctr, Dept Radiat Oncol
Chi Mei Med Ctr, Dept Anesthesiol
Kaohsiung Med Univ,Kaohsiung Med Univ Hosp, Dept Pathol
Chi Mei Med Ctr, Dept Pathol
Natl Hlth Res Inst, Natl Inst Canc Res
Southern Taiwan Univ Sci & Technol, Dept Biotechnol
Chi Mei Med Ctr, Dept Med Image
Dept Leisure Recreat & Tourism Management |
| 關鍵字: | TCN1
Transcobalamin 1
CCRT
chemoradiotherapy
rectal cancer |
| 日期: | 2017 |
| 上傳時間: | 2018-11-30 15:52:56 (UTC+8) |
| 出版者: | Ivyspring Int Publ |
| 摘要: | Objective: Neoadjuvant concurrent chemoradiotherapy (CCRT) is an increasingly common therapeutic strategy for locally advanced rectal cancer, but stratification of risk and final outcomes remain a major challenge. Transcobalamin 1 (TCN1), a vitamin B12 (cobalamin)-binding protein, regulates cobalamin homeostasis. High expression of TCN1 have been reported in neoplasms such as breast cancer and hepatocellular carcinoma. However, little is known about the relevance of TCN1 to rectal cancer receiving CCRT. This study examined the predictive and prognostic impact of TCN1 expression in patients with rectal cancer following neoadjuvant CCRT. Methods: Through data mining from a published transcriptome of rectal cancers (GSE35452), we identified upregulation of TCN1 gene as the most significantly predicted poor response to CCRT among ion transport-related genes (GO: 0006811). We evaluated TCN1 immunohistochemistry and performed an H-score analysis on endoscopic biopsy specimens from 172 rectal cancer patients receiving neoadjuvant CCRT followed by curative surgery. Expression levels of TCN1 were further correlated with clinicopathologic features, therapeutic response, tumor regression grade (TRG) and survivals including metastasis-free survival (MeFS), disease-specific survival (DSS) and recurrent-free survival (LRFS). Results: TCN1 overexpression was significantly related to advanced post-treatment tumor (T3, T4; p<0.001) and nodal status (N1, N2; p<0.001), vascular invasion (p=0.003) and inferior tumor regression grade (p < 0.001). In survival analyses, TCN1 overexpression was significantly associated with shorter DSS (p<0.0001), MeFS (p=0.0002) and LRFS (p=0.0001). Furthermore, it remained an independent prognosticator of worse DSS (p=0.002, hazard ratio=3.344), MeFS (p=0.021, hazard ratio=3.015) and LRFS (p=0.037, hazard ratio=3.037) in the multivariate comparison. Conclusion: Overexpression of TCN1 is associated with poor therapeutic response and adverse outcomes in rectal cancer patients receiving CCRT, justifying the potential prognostic value of TCN1 in rectal cancer receiving CCRT. |
| 關聯: | Journal of Cancer, v.8, n.8, pp.1330-1337 |
| 顯示於類別: | [藥學系(所)] 期刊論文
[保健營養系(所) ] 期刊論文
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