Close correlation between the ankle-brachial index and symptoms of depression in hemodialysis patients

doi:10.1007/s11255-017-1598-7

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Title:	Close correlation between the ankle-brachial index and symptoms of depression in hemodialysis patients
Authors:	Jong, Ing-Chin Tsai, Hung-Bin Lin, Chien-Hung Ma, Tsung-Liang Guo, How-Ran Hung, Peir-Haur Hung, Kuan-Yu
Contributors:	Ditmanson Med FdnChia Yi Christian Hosp, Dept Internal Med, Div Nephrol Natl Taiwan Univ Hosp, Dept Tramatol Natl Yang Ming Univ, Inst Clin Med Taipei City Hosp, Zhongxing Branch, Dept Pediat Natl Cheng Kung Univ, Dept Environm & Occupat Hlth, Med Coll Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth Natl Taiwan Univ Hosp, Hsin Chu Branch, Dept Internal Med
Keywords:	Ankle-brachial index Beck depression inventory Depression Hemodialysis
Date:	2017-08
Issue Date:	2018-11-30 15:52:28 (UTC+8)
Publisher:	Springer
Abstract:	As both of peripheral arterial disease (PAD) and depression carried a poor prognosis in patients on maintenance hemodialysis (MHD), we investigated the correlation between the ankle-brachial index (ABI), an indicator of subclinical PAD, and symptoms of depression in patients on MHD. One hundred and twenty-nine patients on MHD (75 males and 54 females, mean age 64.8 +/- 12 years) were enrolled in this cross-sectional study, which aimed at evaluating the relationship between symptoms of depression and ABI. Demographic as well as clinical and laboratory variables including status of diabetes, chronic hepatitis C infection, dialysis duration, Charlson comorbidity index (CCI), plasma levels of albumin, C-peptide, insulin, high-sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6), adiponectin, and lipid profile were obtained. The self-administered beck depression inventory (BDI) was used to determine the presence or absence of symptoms of depression, and depression was defined as a BDI score ae 14. Multivariable-adjusted linear regression models were constructed to confirm the independent association of biologic parameters of symptoms of depression. Significance was defined as P < 0.05. Statistical analyses were performed using SPSS/Windows software (SPSS Science, v. 15.0, Chicago, IL). The mode of multivariate analysis showed that diabetes (beta = 3.594; P = 0.040), hepatitis C infection (beta = 4.057; P = 0.008), levels of serum albumin (beta = -5.656; P = 0.024), C-peptide (beta = -0.292; P = 0.002), ABI (beta = -9.041; P = 0.031), and Ln-transformed hsCRP were significantly associated with BDI. Hepatitis C infection, serum levels of albumin, C-peptide, and ABI levels were found to be correlated with BDI (P < 0.05).
Relation:	International Urology and Nephrology, v.49, n.8, pp.1463-1470
Appears in Collections:	[Dept. of Life and Health Science] Periodical Articles

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