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| 標題: | E2/ER beta Enhances Calcineurin Protein Degradation and PI3K/Akt/MDM2 Signal Transduction to Inhibit ISO-Induced Myocardial Cell Apoptosis |
| 作者: | Lin, Kuan-Ho
Kuo, Wei-Wen
Shibu, Marthandam Asokan
Day, Cecilia-Hsuan
Hsieh, You-Liang
Chung, Li-Chin
Chen, Ray-Jade
Wen, Su-Ying
Viswanadha, Vijaya Padma
Huang, Chih-Yang |
| 貢獻者: | China Med Univ, Coll Med
China Med Univ Hosp, Dept Emergency Med
China Med Univ, Dept Biol Sci & Technol
China Med Univ, Grad Inst Basic Med Sci
Meiho Univ, Dept Nursing
Asia Univ, Dept Hlth & Nutr Biotechnol
Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
Taipei Med Univ, Coll Med, Sch Med
Taipei City Hosp, Renai Branch
Bharathiar Univ, Dept Biotechnol
China Med Univ, Grad Inst Chinese Med Sci |
| 關鍵字: | 17 beta-Estradiol
calcineurin
cardiac apoptosis
isoproterenol
apoptosis |
| 日期: | 2017-04 |
| 上傳時間: | 2018-11-30 15:52:17 (UTC+8) |
| 出版者: | Mdpi Ag |
| 摘要: | Secretion of multifunctional estrogen and its receptor has been widely considered as the reason for markedly higher frequency of heart disease in men than in women. 17 beta-Estradiol (E2), for instance, has been reported to prevent development of cardiac apoptosis via activation of estrogen receptors (ERs). In addition, protein phosphatase such as protein phosphatase 1 (PP1) and calcineurin (PP2B) are also involved in cardiac hypertrophy and cell apoptosis signaling. However, the mechanism by which E2/ER beta suppresses apoptosis is not fully understood, and the role of protein phosphatase in E2/ER beta action also needs further investigation. In this study, we observed that E2/ER beta inhibited isoproterenol (ISO)-induced myocardial cell apoptosis, cytochrome c release and downstream apoptotic markers. Moreover, we found that E2/ER beta blocks ISO-induced apoptosis in H9c2 cells through the enhancement of calcineurin protein degradation through PI3K/Akt/MDM2 signaling pathway. Our results suggest that supplementation with estrogen and/or overexpression of estrogen receptor beta gene may prove to be effective means to treat stress-induced myocardial damage. |
| 關聯: | International Journal of Molecular Sciences, v.18, n.4, pp.892 |
| 顯示於類別: | [醫務管理系(所)] 期刊論文
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