Anti-Inflammatory Activity and Bioactive Constituents of Cultivated Fruiting Bodies of Xylaria nigripes (Ascomycetes), a Chinese Medicinal Fungus

doi:10.1615/IntJMedMushrooms.2017024404

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 保健營養系(所) > 期刊論文 > Item 310902800/31669

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標題:	Anti-Inflammatory Activity and Bioactive Constituents of Cultivated Fruiting Bodies of Xylaria nigripes (Ascomycetes), a Chinese Medicinal Fungus
作者:	Liaw, Chih-Chuang Wu, Shu-Jing Chen, Ching-Fu Lai, Ming-Nan Ng, Lean-Teik
貢獻者:	Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Natl Taiwan Univ, Dept Agr Chem Kang Jian Biotech Co Ltd
關鍵字:	anti-inflammatory bioactive compounds medicinal mushroom Xylaria nigripes
日期:	2017
上傳時間:	2018-11-30 15:52:15 (UTC+8)
出版者:	Begell House Inc
摘要:	Xylaria nigripes, also known as Wu Ling Shen, is popular for treating insomnia and trauma in traditional Chinese medicine. This study aimed to examine the anti-inflammatory activity and bioactive constituents of cultivated X. nigripes fruiting bodies in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. Results showed that among the different extracts, the hexane fraction exhibited the best protection against cell toxicity induced by 1 mu g/mL LPS and the strongest inhibitory effect on nitric oxide (NO) production. This fraction led to the isolation of 2 bioactive compounds (namely, XN-CP1 and XN-CP2), which were confirmed to be ergostarien-3 beta-ol and ergosterol peroxide, respectively. Although both XN-CP1 and XN-CP2 showed good inhibitory effects on NO, tumor necrosis factor-a, interleukin (IL)-1 beta, IL-6, and prostaglandin E-2 production in LPS-stimulated macrophages, XN-CP2 was shown to have a stronger anti-inflammatory activity; this was further supported by its strong suppressive effects on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression and nuclear factor (NF)-kappa B activation. These results conclude that ergosterol peroxide (XN-CP2) could be the main bioactive compound contributing to the potent anti-inflammatory activity of X. nigripes, and its mechanism of action is mediated through inhibition of iNOS and COX-2 expression via the NF-kappa B signaling pathway.
關聯:	International Journal of Medicinal Mushrooms, v.19, n.10, pp.915-924
顯示於類別:	[保健營養系(所) ] 期刊論文

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