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| 標題: | Hepatoprotective effects of raspberry (Rubus coreanus Miq.) seed oil and its major constituents |
| 作者: | Teng, Hui
Lin, Qiyang
Li, Kang
Yuan, Benyao
Song, Hongbo
Peng, Hongquan
Yi, Lunzhao
Wei, Ming-Chi
Yang, Yu-Chiao
Battino, Maurizio
Cespedes Acuna, Carlos L.
Chen, Lei
Xiao, Jianbo |
| 貢獻者: | Fujian Agr & Forestry Univ, Coll Food Sci
Kiang Wu Hosp, Macau
Kunming Univ Sci & Technol, Yunnan Food Safety Res Inst
Chia Nan Univ Pharm & Sci, Dept Appl Geoinformat
Kaohsiung Med Univ, Dept & Grad Inst Pharmacol
Univ Europea Atlantico, Ctr Nutr & Hlth
Univ Europea, Univ Nutr & Hlth, Dept Clin Sci
Univ Bio Bio, Basic Sci Dept, Plant Biochem & Phytochem Ecol Lab
Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med |
| 關鍵字: | Raspberry seeds
Fatty acids
Extraction
Antioxidant enzyme
Hepatoprotection |
| 日期: | 2017-12 |
| 上傳時間: | 2018-11-30 15:51:29 (UTC+8) |
| 出版者: | Pergamon-Elsevier Science Ltd |
| 摘要: | Raspberry seed is a massive byproduct of raspberry juice and wine but usually discarded. The present study employed a microwave-assisted method for extraction of raspberry seed oil (RSO). The results revealed that omega-6 fatty acids (linoleic acid and gamma-linolenic acid) were the major constituents in RSO. Cellular antioxidant enzyme activity such as superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were investigated in HepG2 cells treated with RSO. Induction of the synthesis of several antioxidants in H2O2-exposed HepG2 cells was found. RSO increased the enzyme activity of SOD, CAT, and GPx in H2O2-exposed HepG2. Furthermore, RSO inhibited the phosphorylation of upstream mitogen-activated protein kinases (MAPK) such as c-Jun N-terminal kinase (c-JNK)and extracellular signal-regulated kinase (ERK). Taken together, the possible mechanisms to increase antioxidant enzyme activities in HepG2 may through the suppression of ERK and JNK phosphorylation. Raspberry seed oil exhibited good effects on the activities of the intracellular antioxidant enzymes and seems to protect the liver from oxidative stress through the inhibition of MAPKs. (C) 2017 Published by Elsevier Ltd. |
| 關聯: | Food and Chemical Toxicology, v.110, pp.418-424 |
| 顯示於類別: | [應用空間資訊系(所)] 期刊論文
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