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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/31647

    標題: Ameliorative effects of pepsin-digested chicken liver hydrolysates on development of alcoholic fatty livers in mice
    作者: Lin, Yi-Ling
    Tai, Szu-Yun
    Chen, Jr-Wei
    Chou, Chung-Hsi
    Fu, Shih-Guei
    Chen, Yi-Chen
    貢獻者: Natl Taiwan Univ, Dept Anim Sci & Technol
    Execut Yuan, Council Agr, Dept Anim Ind, Poultry Ind Sect
    Natl Taiwan Univ, Sch Vet Med
    Natl Taiwan Univ, Zoonoses Res Ctr
    Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth
    關鍵字: Necrosis-Factor-Alpha
    Antioxidant Properties
    Hepatic Steatosis
    日期: 2017-05-01
    上傳時間: 2018-11-30 15:51:27 (UTC+8)
    出版者: Royal Soc Chemistry
    摘要: With developments in economics and increasing work loads, alcohol abuse becomes more and more severe, leading to occurrences of alcoholic liver disease (ALD). Pepsin-digested chicken liver hydrolysates (CLHs) contain high amounts of glutamic acid, leucine, lysine, and alanine while the contents of taurine, anserine, and carnosine are also elevated after pepsin hydrolyzation. The objectives of this study were to evaluate the protective effects of CLHs against chronic alcohol consumption. The results indicated that the enlarged (p < 0.05) sizes of liver and spleen, and serum AST, ALT, and ALKP levels of mice fed with an alcoholic diet were ameliorated by supplementing with CLHs. Moreover, increased hepatic immunocyte infiltration shown on the H&E staining and higher (p < 0.05) hepatic triglyceride contents, TBARS values, and proinflammatory cytokine levels in alcoholic diet fed mice were also reduced (p < 0.05) by supplementing with CLHs. Those benefits were attributed to up-regulated fatty acid beta-oxidation and down-regulated fatty acid synthesis, as well as increased (p < 0.05) SOD, CAT, and GPx activities, TEAC levels, and elevated alcohol metabolic enzymatic activities (ALDH).
    關聯: Food & Function, v.8, n.5, pp.1763-1774
    Appears in Collections:[生活應用與保健系] 期刊論文

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