Increased Risk of Dementia in Patients with Non-Apnea Sleep Disorder

doi:10.2174/1567205013666161108104703

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Title:	Increased Risk of Dementia in Patients with Non-Apnea Sleep Disorder
Authors:	Sung, Pi-Shan Yeh, Chih-Ching Wang, Liang-Chao Hung, Peir-Haur Muo, Chih-Hsin Sung, Fung-Chang Chen, Chih-Hung Tsai, Kuen-Jer
Contributors:	Natl Cheng Kung Univ, Inst Clin Med, Coll Med Natl Cheng Kung Univ,Natl Cheng Kung Univ Hosp, Dept Neurol, Coll Med Taipei Med Univ, Sch Publ Hlth, Coll Publ Hlth & Nutr China Med Univ, Dept Publ Hlth Natl Cheng Kung Univ,Natl Cheng Kung Univ Hosp, Dept Surg, Neurosurg Serv,Coll Med Ditmanson Med Fdn, Dept Internal Med,Chia Yi Christian Hosp Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth China Med Univ Hosp, Management Off Hlth Data China Med Univ, Grad Inst Clin Med Sci, Sch Med, Coll Med Natl Cheng Kung Univ,Natl Cheng Kung Univ Hosp, Coll Med, Ctr Clin Med
Keywords:	Cognitive disorders dementia epidemiology non-apnea sleep disorder retrospective study sleep disorders
Date:	2017
Issue Date:	2018-11-30 15:50:40 (UTC+8)
Publisher:	Bentham Science Publ Ltd
Abstract:	Background: Sleep disorders other than sleep apnea (non-apnea sleep disorder, NSD), esp. insomnia and excessive daytime sleepiness, has been reported to induce higher risk of cognitive decline and dementia in previous longitudinal follow-up studies. However, large-scale nationwide populationbased study may further confirm the association between NSD and dementia. Methods: It was a nationwide population-based retrospective study. We used data from Taiwan's National Health Insurance Research Database (NHIRD) between January 2000 and December 2011. The NSD cohort comprised 92,079 patients aged over 20 years with no preexisting dementia. The comparison cohort was propensity-score matched 1: 1 with 92079 controls. Incident dementia cases were identified to the end of 2011. The NSD cohort to non-NSD cohort adjusted hazard ratios (aHRs) of dementia were assessed using multivariable Cox proportional hazards regression analysis. Results: Incidence of dementia was 4.19 and 2.95 per 1,000 person-years in the NSD and non-NSD cohorts, respectively, with an aHR of 1.46 (95% CI= 1.38-1.54; p<0.0001). Risk of dementia was higher in both gender and whole age subgroup, with slightly higher in men (aHR: 1.48, 95% CI= 1.35-1.62, p<0.0001) and in the younger population (aHR: 2.79, 95% CI= 1.63-4.78, p<0.0001). Dementia was most likely to occur in the first year of follow-up (aHR: 1.73, 95% CI= 1.49-2.02; p<0.0001), but dementia risk remained high 5 years after NSD diagnosis compared to controls (aHR: 1.44, 95% CI= 1.32-1.57; p<0.0001). Conclusion: NSD may be an early indicator of decline in cognitive functioning and onset of dementia in the short-term period. It also carries a higher risk for dementia in the long run. Patients with NSD should require close monitoring for cognitive decline.
Relation:	Current Alzheimer Research, v.14, n.3, pp.309-316
Appears in Collections:	[Dept. of Life and Health Science] Periodical Articles

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