Hyperbaric Oxygen Therapy Is Associated With Lower Short- and Long-Term Mortality in Patients With Carbon Monoxide Poisoning

doi:10.1016/j.chest.2017.03.049

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 藥學系(所) > 期刊論文 > Item 310902800/31618

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標題:	Hyperbaric Oxygen Therapy Is Associated With Lower Short- and Long-Term Mortality in Patients With Carbon Monoxide Poisoning
作者:	Huang, Chien-Cheng Ho, Chung-Han Chen, Yi-Chen Lin, Hung-Jung Hsu, Chien-Chin Wang, Jhi-Joung Su, Shih-Bin Guo, How-Ran
貢獻者:	Chi Mei Med Ctr, Dept Emergency Med Chi Mei Med Ctr, Dept Geriatr & Gerontol Chi Mei Med Ctr, Dept Occupat Med Chi Mei Med Ctr, Dept Med Res Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth Southern Taiwan Univ Sci & Technol, Bachelor Program Senior Serv Southern Taiwan Univ Sci & Technol, Dept Biotechnol Southern Taiwan Univ Sci & Technol, Dept Leisure Recreat & Tourism Management Chia Nan Univ Pharm & Sci, Dept Pharm Taipei Med Univ, Dept Emergency Med Natl Cheng Kung Univ Hosp, Dept Occupat & Environm Med
關鍵字:	carbon monoxide poisoning hyperbaric oxygen therapy mortality
日期:	2017-11
上傳時間:	2018-11-30 15:50:26 (UTC+8)
出版者:	Elsevier Science Bv
摘要:	BACKGROUND: To date, there has been no consensus about the effect of hyperbaric oxygen therapy (HBOT) on the mortality of patients with carbon monoxide poisoning (COP). This retrospective nationwide population-based cohort study from Taiwan was conducted to clarify this issue. METHODS: Using the Nationwide Poisoning Database, we identified 25,737 patients with COP diagnosed between 1999 and 2012, including 7,278 patients who received HBOT and 18,459 patients who did not. The mortality risks of the two cohorts were compared, including overall mortality, and stratified analyses by age, sex, underlying comorbidities, monthly income, suicide attempt, drug poisoning, acute respiratory failure, and follow-up until 2013 were conducted. We also tried to identify independent mortality predictors and evaluated their effects. RESULTS: Patients who received HBOT had a lower mortality rate compared with patients who did not (adjusted hazard ratio [AHR], 0.74; 95% CI, 0.67-0.81) after adjusting for age, sex, underlying comorbidities, monthly income, and concomitant conditions, especially in patients younger than 20 years (AHR, 0.45; 95% CI, 0.26-0.80) and those with acute respiratory failure (AHR, 0.43; 95% CI, 0.35-0.53). The lower mortality rate was noted for a period of 4 years after treatment of the COP. Patients who received two or more sessions of HBOT had a lower mortality rate than did those who received HBOT only once. Older age, male sex, low monthly income, diabetes, malignancy, stroke, alcoholism, mental disorders, suicide attempts, and acute respiratory failure were also independent mortality predictors. CONCLUSIONS: HBOT was associated with a lower mortality rate in patients with COP, especially in those who were younger than 20 years and those with acute respiratory failure. The results provide important references for decision-making in the treatment of COP.
關聯:	Chest, v.152, n.5, pp.943-953
显示于类别:	[藥學系(所)] 期刊論文

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