Biotransformation of Ergostane Triterpenoid Antcin K from Antrodia cinnamomea by Soil-Isolated Psychrobacillus sp AK 1817

doi:10.3390/catal7100299

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題名:	Biotransformation of Ergostane Triterpenoid Antcin K from Antrodia cinnamomea by Soil-Isolated Psychrobacillus sp AK 1817
作者:	Chiang, Chien-Min Wang, Tzi-Yuan Ke, An-Ni Chang, Te-Sheng Wu, Jiumn-Yih
貢獻者:	Chia Nan Univ Pharm & Sci, Dept Biotechnol Acad Sinica, Biodivers Res Ctr Natl Univ Tainan, Dept Biol Sci & Technol Natl Quemoy Univ, Dept Food Sci
關鍵詞:	Antrodia cinnamomea biotransformation antcin K triterpenoid Psychrobacillus
日期:	2017-10
上傳時間:	2018-11-30 15:50:12 (UTC+8)
出版者:	Mdpi Ag
摘要:	Antcin K is one of the major ergostane triterpenoids from the fruiting bodies of Antrodia cinnamomea, a parasitic fungus that grows only on the inner heartwood wall of the aromatic tree Cinnamomum kanehirai Hay (Lauraceae). To search for strains that have the ability to biotransform antcin K, a total of 4311 strains of soil bacteria were isolated, and their abilities to catalyze antcin K were determined by ultra-performance liquid chromatography analysis. One positive strain, AK 1817, was selected for functional studies. The strain was identified as Psychrobacillus sp., based on the DNA sequences of the 16S rRNA gene. The biotransformation metabolites were purified with the preparative high-performance liquid chromatography method and identified as antcamphin E and antcamphin F, respectively, based on the mass and nuclear magnetic resonance spectral data. The present study is the first to report the biotransformation of triterpenoids from A. cinnamomea (Antrodia cinnamomea).
關聯:	Catalysts, v.7, n.10, 文獻號碼:299
顯示於類別:	[Dept. of Biotechnology (including master's program)] Periodical Articles

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