Determination of Dextromethophan, Guaifenesin and Benzoate in the Cough Syrup with HPLC

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Title:	Determination of Dextromethophan, Guaifenesin and Benzoate in the Cough Syrup with HPLC
Authors:	SHIH, JIA-SHENG
Contributors:	Department of Pharmacy, Chia Nan University of Pharmacy & Science TANG, TZ-CIANG
Date:	2016-05-10
Issue Date:	2018-05-21 10:34:26 (UTC+8)
Abstract:	HPLC is used to determine the main ingredients, such as dextromethophan, guafenesin, and benzoate in cough syrups. This method has been proved the effectiveness and accuracy of those ingredients determination. With gradient elution, which was comprised of phosphoric acid buffer and acetonitrile, active ingredients, excipients and baseline of degradation products in syrup would be separated within 16 minutes. With various compositions of mobile phase and detection wavelength, the chromatograms showed different results. The amounts of dextromethophan, guaifenesin and benzoate in commercial cough syrups were determined successfully by linear calibration graph with this method.
Relation:	2016 第十屆嘉南藥理大學藥理學院師生研究成果發表會，起迄日：2016/05/10-2016/05/13，地點：嘉南藥理大學國際會議中心一樓
Appears in Collections:	[Dept. of Pharmacy] Proceedings [Pharmacy and Science] 2016

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