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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/31141


    標題: New xanthone and bioactive constituents from Garcinia subelliptica
    作者: Jih-Jung Chen(陳日榮)
    Hsiang-Ruei Liao(廖庠睿)
    Zou-Chu Chen(陳柔竹)
    CHui-Hsuan hand(張僡玹)
    Yi-Ting Yang(楊依庭)
    Min-Hsiu Kuo(郭旻修)
    Yu-Yan Kuo(郭毓晏)
    CJhy-Yih hen(陳志益)
    Dau-Chang Wei(魏道昌)
    貢獻者: Department of Pharmacy,Tajen University
    Graduate Institute of Natural Products,Chang Gung University
    National Chiayi Senior High School
    National Chiayi Girls’ Senior High School
    日期: 2015-11-14
    上傳時間: 2018-03-27 09:34:10 (UTC+8)
    摘要: Garcinia subelliptica Merr. (Guttiferae) is a small-to-medium-sized dioecious tree, distributed throughout Philippines, the Ryukyus, and Taiwan. Benzopyrans, biphenyls, benzophenones, xanthones, benzoylphloroglucinols, phloroglucinols, terpenoids, and their derivatives are widely distributed in plants of the genus Garcinia. Many of these compounds exhibit diverse biological activities, including anti-tubercular, anti-inflammatory, and cytotoxic activities. In a preliminary screening, the methanolic extract of the root of this species showed anti-inflammatory activities in vitro.
    Phytochemical investigation of the stem of this plant has led to the isolation of a new xanthone derivative, garcisubellone (1), and four known compounds (2-5). The structure of new compound 1 was determined through spectroscopic and MS analyses. The anti-inflammatory effects of the isolated compounds from the roots of G. subelliptica were evaluated by suppressing fMet-Leu-Phe (fMLP)-induced O2 generation by human neutrophils. Among the isolated compounds,1,4,5-trihydroxyxanthone(4) exhibited potent inhibition, with IC50 value of 15.6±2.8μM,against formyl-L-methionyl-L-phenylalanine(fMLP)-induced super-oxide anion (O2) generation.
    關聯: 2015台灣藥學年會暨學術研討會,起迄日:2015/11/14,地點:嘉南藥理大學
    Appears in Collections:[藥理學院] 2015台灣藥學年會暨學術研討會

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