| 摘要: | Garcinia subelliptica Merr. (Guttiferae) is a small-to-medium-sized dioecious tree, distributed throughout Philippines, the Ryukyus, and Taiwan. Benzopyrans, biphenyls, benzophenones, xanthones, benzoylphloroglucinols, phloroglucinols, terpenoids, and their derivatives are widely distributed in plants of the genus Garcinia. Many of these compounds exhibit diverse biological activities, including anti-tubercular, anti-inflammatory, and cytotoxic activities. In a preliminary screening, the methanolic extract of the root of this species showed anti-inflammatory activities in vitro.
Phytochemical investigation of the stem of this plant has led to the isolation of a new xanthone derivative, garcisubellone (1), and four known compounds (2-5). The structure of new compound 1 was determined through spectroscopic and MS analyses. The anti-inflammatory effects of the isolated compounds from the roots of G. subelliptica were evaluated by suppressing fMet-Leu-Phe (fMLP)-induced O2 generation by human neutrophils. Among the isolated compounds,1,4,5-trihydroxyxanthone(4) exhibited potent inhibition, with IC50 value of 15.6±2.8μM,against formyl-L-methionyl-L-phenylalanine(fMLP)-induced super-oxide anion (O2) generation. |
