Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/31139
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    標題: New anti-inflammatory natural products from Pittosporum illicioides var. illicioides
    作者: Ming-Chi Hung(洪明吉)
    Sheng-Ping Huang(黃聖評)
    Tsong-Long Hwang(黃聰龍)
    Ih-Sheng Chen(陳益昇)
    Jih-Jung Chen(陳日榮)
    貢獻者: Department of Pharmacy,Tajen University
    Graduate Institute of Biotechnology,Tajen University
    Graduate Institute of Natural Products,Chang Gung University
    School of Pharmacy ,Kaohsiung Medical University
    日期: 2015-11-14
    上傳時間: 2018-03-27 09:34:08 (UTC+8)
    摘要: Pittosporum illicioides var. illicioides is an evergreen shrub, distributed throughout China and Taiwan. Phthalides, carotenoids, tritepenoid saponins, sesquiterpene glycosides, and their derivatives are widely distributed in plants of the genus Pittosporum. Many of these compounds exhibit diverse biological activities, including antimicrobial and cytotoxic activities. In our studies on the anti-inflammatory constituents of Formosan plants, many species have been screen for in vitro anti-inflammatory activity, and P. illicioides var. illicioides has been found to be an active species. Phytochemical investigation of the stem of this plant has led to the isolation of three new phthalide derivatives, (S)-3-ethyl-5,7-dihydroxy-6-methoxyphthalide(1), (R)-3-ethyl-7-hydroxy-5,6-dimethoxyphthalide(2), and (R)-3-ethyl-4,7-dimethoxyphthalide(3), and six known compounds (4-9). The structures of new compounds (1-3)were determined through spectroscopic and MS analyses. Among the isolated compounds, (S)-3-ethyl-5,7-dihydroxy-6-methoxyphthalide(1) and (R)-3-ethyl-7-hydroxy-5,6-dimethoxyphthalide(2) inhibited fMLP/CB-induced elastase release with IC50 values of 1.70±0.24 and 1.02±0.36 μg/mL, respectively.
    關聯: 2015台灣藥學年會暨學術研討會，起迄日：2015/11/14，地點：嘉南藥理大學
    顯示於類別:[藥理學院] 2015台灣藥學年會暨學術研討會

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