| 摘要: | Pittosporum illicioides var. illicioides is an evergreen shrub, distributed throughout China and Taiwan. Phthalides, carotenoids, tritepenoid saponins, sesquiterpene glycosides, and their derivatives are widely distributed in plants of the genus Pittosporum. Many of these compounds exhibit diverse biological activities, including antimicrobial and cytotoxic activities. In our studies on the anti-inflammatory constituents of Formosan plants, many species have been screen for in vitro anti-inflammatory activity, and P. illicioides var. illicioides has been found to be an active species. Phytochemical investigation of the stem of this plant has led to the isolation of three new phthalide derivatives, (S)-3-ethyl-5,7-dihydroxy-6-methoxyphthalide(1), (R)-3-ethyl-7-hydroxy-5,6-dimethoxyphthalide(2), and (R)-3-ethyl-4,7-dimethoxyphthalide(3), and six known compounds (4-9). The structures of new compounds (1-3)were determined through spectroscopic and MS analyses. Among the isolated compounds, (S)-3-ethyl-5,7-dihydroxy-6-methoxyphthalide(1) and (R)-3-ethyl-7-hydroxy-5,6-dimethoxyphthalide(2) inhibited fMLP/CB-induced elastase release with IC50 values of 1.70±0.24 and 1.02±0.36 μg/mL, respectively. |
