Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/31138
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    標題: Five aromatic components ameliorated trinitrobenzene sulphonic acid-induced colitis in mice
    作者: Chun-Chiao Chiu(邱純嬌)
    Li-Ying Huang(黃麗螢)
    Yi-Hsuan Lee(李怡萱)
    Chien-Yun Hsiang(項千芸)
    Tin-Yun Ho(侯庭鏞)
    Jaw-Chyun Chen(陳兆群)
    貢獻者: Department of Medicinal Botany and Healthcare,Da-Yeh University
    Department of Microbiology,China Medical University
    Graduate Institute of Chinese Medicine,China Medical University
    日期: 2015-11-14
    上傳時間: 2018-03-27 09:34:07 (UTC+8)
    摘要: Inflammatory bowel disease (IBD) are important gastrointestinal disease by dysregulated mucosal cytokine imbalance leading to inflammation and mucosal damage,and to subsequent fibrosis.At present,all of the anti-inflammatory drugs,such as 5-aminosalicylic acid,and immunosuppression drugs,such as glucocorticoids,have been used for the treatment of IBD.However,these drugs often induce various side effects that limit their use.Many people add spice(s) in diet not only to increase appetite,but also promote health.Therefore,we investigated the therapeutic effects of 5 aromatic components(zingerone,vanillin,eugenol,anethole,and capsaicin)in mice with 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis.Induction of colitis and treatment:TNBS in 0.1 ml of 50% ethanol was administered into the colon of a anesthetized mouse via a thin catheter attached to a syringe.Anethole is the most active component that improved both macro and microscopic colitis severity in a dose-dependent manner.Pathway analysis of anethole-regulated gene expression profiles showed that anethole significantly regulated IL6,TNF,TGF-β,cytokine,and cytokine-cytokine receptor interaction pathways.Immunohistochemical staining results indicated that anethole down-regulated the TNFα,TGF-β1,and IL6 protein levels in the expression of anethole-affected genes.Ex vivo imaging and immunohistochemical staining further verified that anethole suppressed TNBS-induced NF-κB activation and IL-1β protein level in the colon.
    關聯: 2015台灣藥學年會暨學術研討會，起迄日：2015/11/14，地點：嘉南藥理大學
    显示于类别:[藥理學院] 2015台灣藥學年會暨學術研討會

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