Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/31137
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 18074/20272 (89%)
造访人次 : 2592530      在线人数 : 1213
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/31137


    標題: Chemical investigation of Hyptis suaveolens guided by xanthine oxidase inhibitory activity (I)
    作者: Yi-Li Lin(林義力)
    Shoei-Sheng Lee(李水盛)
    貢獻者: School of Pharmacy,College of Medicine,National Taiwan University
    日期: 2015-11-14
    上傳時間: 2018-03-27 09:34:06 (UTC+8)
    摘要: Gout is a kind of metabolic disease,caused by accumulation of uric acid crystals in the joints.Xanthine oxidase plays an important role in the production of uric acid.Thus,its inhibitor,allopurinol,is often used clinically for long-term gout therapy.This drug,however,might cause Stevens-Johnson syndrome.Therefore,the search for alternative drugs for treating gout is still in need.Our recent studies indicated that some constituents from Hyptis rhomboids are potent xanthine oxidase inhibitors.Thus the aim of this research was to investigate whether the chemical constituents of the related native species,H. suaveolens,possess similar activity.
    The ethanol extract of H. suaveolens stem was divided into fractions soluble in CH2Cl2,EtOAc,n-BuOH,and water via liquid-liquid partitioning.Further separation was conducted on the EtOAc-soluble fraction,which possesses the best anti-xanthine oxidase activity among these fractions.This effort led to the isolation of 14 compounds by combination of Sephadex LH-20,silica gel and reverse-phase columns,and semi-preparative RP-HPLC.Of these,two are new,i.e.,9’-methyl melitrate A and dimethyl melitrate A.The 12 known ones were identified as rosmarinic acid,caffeic acid,methyl melitrate A,melitric acid A,netpetoidin B,danshensu,methyl rosmarinate,oresbiusin A,ursolic acid,sagecoumarin, netpetoidin A,kaempferol-3-O-(4-O-acetyl-α-L-rhamnopyranoside).Their structures were elucidated by MS data and NMR(1D and 2D)spectroscopic analysis.
    Through xanthine oxidase bioassay, netpetoidin A was found to possess the best inhibitory activity with the IC50 values of 11.7μM(cf. allopurinol 5.3μM).
    關聯: 2015台灣藥學年會暨學術研討會，起迄日：2015/11/14，地點：嘉南藥理大學
    显示于类别:[藥理學院] 2015台灣藥學年會暨學術研討會

    文件中的档案:

    档案 描述 大小格式浏览次数
    PA-15.pdf32KbAdobe PDF390检视/开启


    在CNU IR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈