Cytotoxic constituents from Strophanthus divaricatus

CNU IR > Pharmacy and Science > 2015 Annual symposium of the pharmaceutical society of Taiwan > Item 310902800/31135

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Title:	Cytotoxic constituents from Strophanthus divaricatus
Authors:	Wei-Yu Lin(林威宇) Yu-Chang Chen(陳昱璋) Jing-Ru Weng(翁靖如)
Contributors:	Department of Pharmacy, Kinmen Hospital, Ministry of Heaith and Welfare Department of Pharmacy, China Medical University Hospital Department of Biological Science and Technology, China Medical University
Date:	2015-11-14
Issue Date:	2018-03-27 09:34:04 (UTC+8)
Abstract:	Strophanthus divaricatus is a small evergreen shrubs which is rarely found in Taiwan. The Genus Strophanthus is well known for producing cardiac glycosides and some of which exhibiting antitumor activity. Isolates were purified by silica gel. Structural elucidation were accomplished by H-C-NMR, HMBC, HMQC, COSY, NOESY and MS spectra. Cytotoxicity were evaluated by MTT assay. Through the screening on the basis of the two different types of cancers, including oral cancer (SCC-2095) and acute myeloid leukemia (THP-1), the crude extract of S.divaricatus (SD) possessed cytotoxicity in this screening against these two cancer cell lines. The IC50 value of SD is about at 0.96-1.37μg/mL after 48hrs treatment. The isolation and characterization of one cardenolide cardiac glycoside, divostroside was also reported. This potent anti-tumor action of SD suggested that might be potential value to do the further investigation of its anticancer activity.
Relation:	2015台灣藥學年會暨學術研討會，起迄日：2015/11/14，地點：嘉南藥理大學
Appears in Collections:	[Pharmacy and Science] 2015 Annual symposium of the pharmaceutical society of Taiwan

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