Studies on the bioactive chemical constituents of Lespedeza cuneata

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標題:	Studies on the bioactive chemical constituents of Lespedeza cuneata
作者:	Cheng-I Wu (吳政毅) Yu-Ling Huang (黃鈺玲) Chia-Chuan Chang (張嘉銓)
貢獻者:	Institute of Genome Sciences, National Yang-Ming University Division of Chinese Medicinal Chemistry School of Pharmacy, National Taiwan Unicersity
日期:	2015-11-14
上傳時間:	2018-03-27 09:33:52 (UTC+8)
摘要:	Neovascularization plays a role in several pathological conditions, including tumor growth, arthritis, and choroidal neovascularization. Preliminary in vitro Matrigel angiogenesis assays on the EtOH extracts of Chinese herbal medicine revealed that the hexane layer of Lespedeza cuneata was active against the formation of tube-like structures on Matrigel. L. cuneata is a perennial legume distributed in Korea, China, India, Australia and Taiwan and used as folk anti-inflammatory medicine. By anti-angiogenetic activity-guided silica gel chromatography of the hexane layer, a low-polarity fraction containing polyunsaturated fatty acids with IC50 of 8μg/ml was obtained. It had been proved that long chain n-3 polyunsaturated fatty acids have anti-angiogenic effect in intestinal microvascular endothelium. We also isolated and identified 3 triterpenes (LC-3 & 4) among which stigmasterol and ß-sitosterol had been reported to have anti-inflammatory properties along with two other compounds, salicylic acid (LC-1) and (65,7E)-vomifoliol (LC-2).
關聯:	2015台灣藥學年會暨學術研討會，起迄日：2015/11/14，地點：嘉南藥理大學
顯示於類別:	[藥理學院] 2015台灣藥學年會暨學術研討會

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