Glutamine in Alleviation of Radiation-Induced Severe Oral Mucositis: A Meta-Analysis

doi:10.1080/01635581.2016.1159700

CNU IR > College of Smart Living > Dept. of Information Management > Periodical Articles > Item 310902800/31085

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/31085

题名:	Glutamine in Alleviation of Radiation-Induced Severe Oral Mucositis: A Meta-Analysis
作者:	Leung, Henry W. C. Chan, Agnes L. F.
贡献者:	China Med Univ, An Nan Hosp Chia Nan Univ Pharm & Sci, Dept Informat Management Chia Nan Univ Pharm, Dept Pharm
关键词:	placebo-controlled trial locally advanced head neck-cancer chemotherapy prevention chemoradiotherapy transplantation consequences malignancies management
日期:	2016
上传时间:	2018-01-18 11:41:27 (UTC+8)
出版者:	Routledge Journals, Taylor & Francis Ltd
摘要:	The aim of this meta-analysis was to assess the effectiveness of glutamine to treat severe mucositis induced by radiation therapy in patients with head and neck cancer. We undertook electronic searches of PubMed (1990 to January 2015), Embase (1990 to January 2015), and the Cochrane Library (2013, Issue 2) to identify relevant studies. We included randomized controlled trials of glutamine to alleviate oral mucositis (OM) in patients with head and neck cancer who received radiotherapy. Information regarding methods, patients, results, and risk of bias was independently extracted by two authors. Statistical analyses were conducted to calculate the odds ratio and 95% confidence intervals (95%CIs) using fixed-effect models. We identified five clinical studies that included 234 patients with head and neck cancer. All studies were assessed as being at low risk of bias in most items of six domains. In this meta-analysis, glutamine treatment showed a statistically significant benefit with respect to reducing the risk and severity of OM induced by radiotherapy compared to either placebo or no treatment (risk ratio 0.17, 95%CI 0.06-0.47). Overall, glutamine significantly reduces the risk and severity of OM during radiotherapy or chemotherapy. Further prospective and large trials are required to support the findings.
關聯:	Nutrition and Cancer-An International Journal, v.68 n.5, pp.734-742
显示于类别:	[Dept. of Pharmacy] Periodical Articles [Dept. of Information Management] Periodical Articles

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	1776	检视/开启

在CNU IR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....