Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/31082
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    Title: Multiple Brain Abscesses Due to Aspergillus Fumigatus in a Patient With Liver Cirrhosis A Case Report
    Authors: Tang, Hung-Jen
    Liu, Wei-Lun
    Chang, Tsung Chain
    Li, Ming-Chi
    Ko, Wen-Chien
    Wu, Chi-Jung
    Chuang, Yin-Ching
    Lai, Chih-Cheng
    Contributors: Chi Mei Med Ctr, Dept MedChia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Chi Mei Med Ctr, Dept Intens Care Med
    Natl Cheng Kung Univ, Coll Med, Dept Med Lab Sci & Biotechnol
    Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Internal Med
    Natl Hlth Res Inst, Natl Inst Infect Dis & Vaccinol
    Chi Mei Med Ctr, Dept Med ResChi Mei Med Ctr, Dept Internal Med
    Date: 2016-03
    Issue Date: 2018-01-18 11:41:23 (UTC+8)
    Publisher: Lippincott Williams & Wilkins
    Abstract: Invasive cerebral aspergillosis always developed in immunocompromised host. Early diagnosis may save life in this critical condition; however, it is difficult to reach. Herein, we presented an unusual case of invasive cerebral aspergillosis in a cirrhotic patient. A 47-year-old man presented with progressive deterioration of consciousness for three days. The patient had a history of alcoholic liver cirrhosis, Child-Pugh class C. Magnetic resonance imaging (MRI) of brain showed multi-focal parenchymal lesions, which was consistent with multiple brain abscesses. The diagnosis of invasive cerebral aspergillosis was made by molecular based laboratory methods including Aspergillus galactomannan antigen assay and oligonucleotide array. Despite treatment with the antifungal agent, Amphotericin B, the patient died at the ninth day of hospitalization. Our findings suggest that liver cirrhosis can be one of risk factors of invasive cerebral aspergillosis, and support the diagnosing usefulness of MRI, Aspergillus galactomannan antigen assay, and oligonucleotide array.
    Relation: Medicine, v.95 n.9, UNSP e2813
    Appears in Collections:[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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