Multiple Brain Abscesses Due to Aspergillus Fumigatus in a Patient With Liver Cirrhosis A Case Report

doi:10.1097/MD.0000000000002813

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/31082

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Title:	Multiple Brain Abscesses Due to Aspergillus Fumigatus in a Patient With Liver Cirrhosis A Case Report
Authors:	Tang, Hung-Jen Liu, Wei-Lun Chang, Tsung Chain Li, Ming-Chi Ko, Wen-Chien Wu, Chi-Jung Chuang, Yin-Ching Lai, Chih-Cheng
Contributors:	Chi Mei Med Ctr, Dept MedChia Nan Univ Pharm & Sci, Dept Hlth & Nutr Chi Mei Med Ctr, Dept Intens Care Med Natl Cheng Kung Univ, Coll Med, Dept Med Lab Sci & Biotechnol Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Internal Med Natl Hlth Res Inst, Natl Inst Infect Dis & Vaccinol Chi Mei Med Ctr, Dept Med ResChi Mei Med Ctr, Dept Internal Med
Date:	2016-03
Issue Date:	2018-01-18 11:41:23 (UTC+8)
Publisher:	Lippincott Williams & Wilkins
Abstract:	Invasive cerebral aspergillosis always developed in immunocompromised host. Early diagnosis may save life in this critical condition; however, it is difficult to reach. Herein, we presented an unusual case of invasive cerebral aspergillosis in a cirrhotic patient. A 47-year-old man presented with progressive deterioration of consciousness for three days. The patient had a history of alcoholic liver cirrhosis, Child-Pugh class C. Magnetic resonance imaging (MRI) of brain showed multi-focal parenchymal lesions, which was consistent with multiple brain abscesses. The diagnosis of invasive cerebral aspergillosis was made by molecular based laboratory methods including Aspergillus galactomannan antigen assay and oligonucleotide array. Despite treatment with the antifungal agent, Amphotericin B, the patient died at the ninth day of hospitalization. Our findings suggest that liver cirrhosis can be one of risk factors of invasive cerebral aspergillosis, and support the diagnosing usefulness of MRI, Aspergillus galactomannan antigen assay, and oligonucleotide array.
Relation:	Medicine, v.95 n.9, UNSP e2813
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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