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| 標題: | Biosynthetic Pathway of the Reduced Polyketide Product Citreoviridin in Aspergillus terreus var. aureus Revealed by Heterologous Expression in Aspergillus nidulans |
| 作者: | Lin, Tzu-Shyang
Chiang, Yi-Ming
Wang, Clay C. C. |
| 貢獻者: | Univ So Calif, Sch Pharm, Dept Pharmacol & Pharmaceut Sci
Chia Nan Univ Pharm & Sci, Dept Pharm
Univ So Calif, Dept Chem, Coll Letters Arts & Sci |
| 關鍵字: | gene clusters
synthase
methylation
metabolites
system
fungus
cells |
| 日期: | 2016-03 |
| 上傳時間: | 2018-01-18 11:41:21 (UTC+8) |
| 出版者: | Amer Chemical Soc |
| 摘要: | Citreoviridin (1) belongs to a class of F1-ATPase beta-subunit inhibitors that are synthesized by highly reducing polyketide synthases. These potent mycotoxins share an alpha-pyrone polyene structure, and they include aurovertin, verrucosidin, and asteltoxin. The identification of the citreoviridin biosynthetic gene cluster in Aspergillus terreus var. aureus and its reconstitution using heterologous expression in Aspergillus nidulans are reported. Two intermediates were isolated that allowed the proposal of the biosynthetic pathway of citreoviridin. |
| 關聯: | Organic Letters, v.18 n.6, pp.1366-1369 |
| 顯示於類別: | [藥學系(所)] 期刊論文
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