Bacteremic Urinary Tract Infection Caused by Multidrug-Resistant Enterobacteriaceae Are Associated With Severe Sepsis at Admission Implication for Empirical Therapy

doi:10.1097/MD.0000000000003694

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標題:	Bacteremic Urinary Tract Infection Caused by Multidrug-Resistant Enterobacteriaceae Are Associated With Severe Sepsis at Admission Implication for Empirical Therapy
作者:	Lee, Yi-Chien Hsiao, Chih-Yen Hung, Miao-Chiu Hung, Sheng-Che Wang, Hung-Ping Huang, Yun-Jhong Wang, Jann-Tay
貢獻者:	Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Internal Med Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm Taipei Vet Gen Hosp, Dept Pediat Taipei Vet Gen Hosp, Dept Radiol Natl Yang Ming Univ, Sch Med Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Colorectal Surg Natl Taiwan Univ Hosp, Dept Internal Med
關鍵字:	escherichia-coli bacteremia risk-factors acute pyelonephritis antimicrobial resistance antibiotic-resistance clinical impact septic shock guidelines prognosis virulence
日期:	2016-05
上傳時間:	2018-01-18 11:41:11 (UTC+8)
出版者:	Lippincott Williams & Wilkins
摘要:	The purpose of this study is to compare the clinical features and treatment outcomes among patients with bacteremic urinary tract infection (UTI) caused by multidrug-resistant (MDR) and non-MDR Enterobacteriaceae and to identify whether MDR pathogens were independently associated with severe sepsis or septic shock at presentation. The clinical data of adult patients visiting and being treated at Chia-Yi Christian Hospital due to bacteremic UTI caused by Enterobacteriaceae from January 2006 to August 2015 were retrospectively analyzed. A total of 585 patientswere enrolled. Among them, 220 (37.6%) were caused by the MDR Enterobacteriaceae. A total of 206 patients (35.2%) developed severe sepsis or septic shock at presentation. Patients in the MDR group tend to be male and have a past history of gout, recurrent UTI, prior hospitalization, hydronephrosis, renal stone, ureteral stone, indwelling urinary catheter, newly development of renal dysfunction, severe sepsis or septic shock, intensive care unit (ICU) admission, receipt of ineffective empirical therapy, longer hospital stay, and higher in-hospital mortality (2.7% vs 1.9%, P = 0.569). Using multivariate logistic regression analysis, it is revealed that independent predictors associated with severe sepsis or septic shock at presentation were liver cirrhosis (OR 2.868; 95% CI 1.439-5.716; P = 0.003), indwelling urinary catheter (OR 1.936; 95% CI 1.238-3.027; P = 0.004), and MDR Enterobacteriaceae (OR 1.447; 95% CI 1.002-2.090; P = 0.049). Multidrug resistance was associated with the development of severe sepsis or septic shock upon presentation among patients with bacteremic UTI caused by Enterobacteriaceae. Therefore, empirical antibiotics therapy for patients with UTI presented with severe sepsis and/or septic shock should be more broad-spectrum to effectively cover MDR Enterobacteriaceae.
關聯:	Medicine, v.95 n.20, e3694
顯示於類別:	[醫務管理系(所)] 期刊論文

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