The Association Between Peptic Ulcer Disease and Ischemic Stroke A Population-Based Longitudinal Study

doi:10.1097/MD.0000000000003797

CNU IR > College of Sustainable Environment and Recreation > Dept. of Occupational Safety > Periodical Articles > Item 310902800/31073

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/31073

Title:	The Association Between Peptic Ulcer Disease and Ischemic Stroke A Population-Based Longitudinal Study
Authors:	Cheng, Tain-Junn Guo, How-Ran Chang, Chia-Yu Weng, Shih-Feng Li, Pi-I Wang, Jhi-Joung Wu, Wen-Shiann
Contributors:	Chi Mei Med Ctr, Dept Neurol Chi Mei Med Ctr, Dept Occupat Med Chia Nan Univ Pharm & Sci, Coll Sustainable Environm, Dept Occupat Safety & Disaster Prevent Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth Natl Cheng Kung Univ Hosp, Dept Occupat & Environm Med Southern Taiwan Univ, Ctr Gen Educ Kaohsiung Med Univ, Dept Healthcare Adm & Med Informat Chi Mei Med Ctr, Dept Family Med Chi Mei Med Ctr, Dept Med Res Chi Mei Med Ctr, Dept Internal Med Chia Nan Univ Pharm & Sci, Dept Pharm
Keywords:	helicobacter-pylori-strains coronary-artery-disease cerebrovascular-disease psychological distress atherosclerotic stroke risk-factor stress men
Date:	2016-05
Issue Date:	2018-01-18 11:41:09 (UTC+8)
Publisher:	Lippincott Williams & Wilkins
Abstract:	Stroke is a common cause of death worldwide, but about 30% of ischemic stroke (IS) patients have no identifiable contributing risk factors. Because peptic ulcer disease (PUD) and vascular events share some common risk factors, we conducted a population-based study to evaluate the association between PUD and IS. We followed up a representative sample of 1 million residents of Taiwan using the National Health Insurance Research Database from 1997 to 2011. We defined patients who received medications for PUD and had related diagnosis codes as the PUD group, and a reference group matched by age and sex was sampled from those who did not have PUD. We also collected data on medical history and monthly income. The events of IS occurred after enrollment were compared between the 2 groups. The data were analyzed using Cox proportional hazard models at the 2-tailed significant level of 0.05. The PUD group had higher income and prevalence of hypertension, diabetes mellitus (DM), heart disease, and hyperlipidemia. They also had a higher risk of developing IS with an adjusted hazard ratio of 1.31 (95% confidence interval: 1.20-1.41). Other independent risk factors included male sex, older age, lower income, and co-morbidity of hypertension, diabetes mellitus (DM), and heart disease. PUD is a risk factor for IS, independent of conventional risk factors such as male sex, older age, lower income, and co-morbidity of hypertension, DM, and heart disease. Prevention strategies taking into account PUD should be developed and evaluated.
Relation:	Medicine, v.95 n.22, e3797
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles [Dept. of Occupational Safety] Periodical Articles

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